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	Provedor de dados BJMBR (1) Autor Cabral,A.L.B. (1) Castro,R.M.R.P.S. (1) Freitas,A.R.O. (1) Martins,V.R. (1) Mercadante,A.F. (1) Palavra-chave Cellular function (1) Copper (1) Laminin (1) PrPc (1) Signal transduction (1) Transmissible spongiform encephalopathies (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2001 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Insights into the physiological function of cellular prion protein BJMBR Martins,V.R.; Mercadante,A.F.; Cabral,A.L.B.; Freitas,A.R.O.; Castro,R.M.R.P.S.. Prions have been extensively studied since they represent a new class of infectious agents in which a protein, PrPsc (prion scrapie), appears to be the sole component of the infectious particle. They are responsible for transmissible spongiform encephalopathies, which affect both humans and animals. The mechanism of disease propagation is well understood and involves the interaction of PrPsc with its cellular isoform (PrPc) and subsequently abnormal structural conversion of the latter. PrPc is a glycoprotein anchored on the cell surface by a glycosylphosphatidylinositol moiety and expressed in most cell types but mainly in neurons. Prion diseases have been associated with the accumulation of the abnormally folded protein and its neurotoxic effects;... Tipo: Info:eu-repo/semantics/article Palavras-chave: PrPc; Cellular function; Transmissible spongiform encephalopathies; Laminin; Signal transduction; Copper. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500005 Registros recuperados: 1 Primeira ... 1 ... Última

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