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	Provedor de dados BJM (2) Ciência Rural (2) Genet. Mol. Biol. (1) Autor Castro-Prado,Marialba Avezum Alves de (5) Busso,Cleverson (2) Chiuchetta,Simone Jurema Ruggeri (2) Catanzaro-Guimarães,Sérgio Augusto (1) Chierice,Gilberto Orivaldo (1) Franco,Claudinéia Conationi da Silva (1) Franco,Francisco de Assis (1) Gonçalves,Evelyn Almeida Lucas (1) Kaneshima,Edilson Nobuyoshi (1) Miyamoto,Claudia Tiemi (1) Querol,Carmen Boto (1) Sant'Anna,Juliane Rocha de (1) Takano,Eunice Hitomi (1) Mais... Palavra-chave Antineoplastic agents (2) Mitotic crossing-over (2) Secondary malignances (2) Atividade antifúngica (1) Conidiation (1) Detergentes (1) Fungos (1) Fusarium graminearum (1) Genetic variability (1) Homozygotization index (1) Mitotic recombination (1) Nitric oxide (1) Parasexual cycle (1) RAPD (1) Vegetative compatibility groups (1) Óleo da mamona (1) Mais... Tipo do documento Info:eu-repo/semantics/article (5) Ano 2007 (3) 2005 (1) 2002 (1) País Brazil (5) Idioma Inglês (4) Português (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Genotoxicity of the cyclo-oxygenase-inhibitor sulindac sulfide in the filamentous fungus Aspergillus nidulans BJM Franco,Claudinéia Conationi da Silva; Miyamoto,Claudia Tiemi; Sant'Anna,Juliane Rocha de; Castro-Prado,Marialba Avezum Alves de. Sulindac sulfide is a non-steroidal anti-inflammatory drug (NSAID) with chemopreventive effect on human cancer cells. Due to the involvement of the somatic recombination in the carcinogenic process, sulindac sulfide's recombinogenic potential was evaluated by the Homozygotization Index (HI) in the filamentous fungus Aspergillus nidulans. The drug's recombinogenic potential was evaluated by its capacity to induce homozygosis of recessive genes from heterozygous diploid cells. Sulindac sulfide at 175 and 350 µM concentrations induced mitotic recombination in A. nidulans diploid cells, with HI values for genetic markers higher than 2.0, and significantly different from control HI values. The recombinogenic effect of NSAID was related to the induction of DNA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Mitotic crossing-over; Secondary malignances. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000300009 Doxorubicin and etoposide induce somatic recombination in diploid cells of Aspergillus nidulans BJM Chiuchetta,Simone Jurema Ruggeri; Castro-Prado,Marialba Avezum Alves de. Doxorubicin and etoposide are intercalating agents that inhibit the action of the enzyme topoisomerase II. Both drugs present therapeutic activity in numerous human neoplasms In the present work the recombinagenic potential of these drugs was evaluated by ascomycete Aspergillus nidulans. Their effects on the asexual cycle of A. nidulans was also appraised. Two heterozygous diploid strains of A. nidulans, a wild (uvsH+//uvsH+) and a defective to the DNA repair (uvsH//uvsH) were used. The drugs' recombinagenic potential was evaluated by their capacity to induce homozygosis of recessive genes from heterozygous cells. Both drugs have a recombinagenic effect on diploid cells of A. nidulans. Doxorubicin and etoposide are potentially capable to induce secondary... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Mitotic crossing-over; Secondary malignances. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822002000300014 Vegetative compatibility and molecular characterization of Fusarium graminearum isolates from the State of Paraná, Brazil Ciência Rural Busso,Cleverson; Kaneshima,Edilson Nobuyoshi; Franco,Francisco de Assis; Querol,Carmen Boto; Castro-Prado,Marialba Avezum Alves de. Fusarium graminearum isolates causing Fusarium head blight in wheat were collected in Brazil and analyzed by random amplified polymorphic DNA (RAPD) markers and vegetative compatibility grouping (VCG). Nitrate non-utilizing mutants (nit) from each isolate were paired to verify heterokaryon formation. Three VCGs were identified among F. graminearum isolates: VCG1 included F-2, F-3 and F-4 isolates; VCG2 included F-1, F-6 and F-9 isolates; VCG3 included F-5, F-7 and F-8 isolates. Based on PCR amplification with eight different primers, the isolates showed great genetic similarity among themselves. Dendrogram analysis demonstrated two RAPD groups: Group A, consisting of isolates F-2 and F-9, and Group B, composed of the remaining isolates. Results suggest the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fusarium graminearum; Genetic variability; RAPD; Vegetative compatibility groups. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000600050 Inibição do desenvolvimento de fungos fitopatogênicos por detergente derivado de óleo da mamona (Ricinus communis) Ciência Rural Takano,Eunice Hitomi; Busso,Cleverson; Gonçalves,Evelyn Almeida Lucas; Chierice,Gilberto Orivaldo; Catanzaro-Guimarães,Sérgio Augusto; Castro-Prado,Marialba Avezum Alves de. No presente estudo avaliou-se o efeito fungitóxico do detergente derivado do óleo da mamona (Ricinus communis) sobre o desenvolvimento dos fitopatógenos: Pyricularia grisea, Fusarium graminearum e Colletotrichum lindemuthianum. Seis concentrações do detergente (12,5mL L-1 a 300mL L-1) foram, individualmente, incorporadas ao Meio Basal; a seguir, após inoculação fúngica, o crescimento radial dos micélios foi avaliado. A inibição total do desenvolvimento de C. lindemuthianum e P. grisea foi observada entre as concentrações de 50mL L-1 e 200mL L-1, respectivamente. Com base no crescimento miceliano das colônias de F. graminearum, a atividade antifúngica do detergente do óleo da mamona (DOM) determinou inibição variável entre 79,4 e 91% para a raça F2 e entre... Tipo: Info:eu-repo/semantics/article Palavras-chave: Atividade antifúngica; Fungos; Óleo da mamona; Detergentes. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000500003 Genotoxic evaluation of sodium nitroprusside in Aspergillus nidulans Genet. Mol. Biol. Chiuchetta,Simone Jurema Ruggeri; Castro-Prado,Marialba Avezum Alves de. The exogenous nitric oxide donor, sodium nitroprusside, evaluated the recombinogenic potential of nitric oxide. Drug inhibited mycelial growth and conidiation in A757 Aspergillus nidulans master strain. Two heterozygous diploid strains, one wild (uvsH+//uvsH+) and the other defective to DNA repair (uvsH//uvsH) were used for recombinagenesis tests. Sodium nitroprusside recombinogenic effect was evaluated by the induction of homozygosis of recessive genes, originally present in heterozygous condition. Results show that sodium nitroprusside (40 muM, 80 muM and 160 muM) is effective in inducing mitotic crossing-over in diploid cells of A. nidulans. Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Parasexual cycle; Homozygotization index; Conidiation; Mitotic recombination. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500023 Registros recuperados: 5 Primeira ... 1 ... Última

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