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	Provedor de dados BABT (2) Autor Amaral,Ademir (2) Cavalcanti,Mariana Brayner (2) Fernandes,Thiago Salazar (1) Machado,Cíntia Gonsalves de Faria (1) Neves,Maria Amélia Batista (1) Santos,Neyliane Gonçalves dos (1) Mais... Palavra-chave Biodosimetry (1) Bioindicators (1) Combined therapy (1) Flow cytometry (1) Functional analysis (1) Multidrug resistance (1) P-glycoprotein (1) Physical Dosimetry (1) Protein expression (1) Radiation effect (1) Radioprotection (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Bioindicators in radiation protection BABT Amaral,Ademir; Fernandes,Thiago Salazar; Cavalcanti,Mariana Brayner. Biodosimetry is the evaluation of absorbed dose using bioindicators. Among chromosomal aberrations, scoring of dicentrics from peripheral human blood has been used as gold standard for biodosimetry, although in case of large scale incidents its use presents some drawbacks. Advances in technology have led to new investigations allowing or permitting the use of new methods which not only improve this "classical" biodosimetry but permits the design of other bioindicators making possible faster analyses, particularly in events where many persons may have been exposed. This report presents an overview of some recent studies developed by the "Grupo de Estudos em Radioproteção e Radioecologia - GERAR", Nuclear Energy Department of UFPE - Brazil, involving... Tipo: Info:eu-repo/semantics/article Palavras-chave: Biodosimetry; Physical Dosimetry; Radioprotection; Bioindicators; Protein expression. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700015 Flow cytometry protocol to evaluate ionizing radiation effects on P-glycoprotein activity BABT Santos,Neyliane Gonçalves dos; Amaral,Ademir; Cavalcanti,Mariana Brayner; Neves,Maria Amélia Batista; Machado,Cíntia Gonsalves de Faria. The aim of this work was to establish a protocol to evaluate ionizing radiation effects on P-glycoprotein (P-gp) activity. For this, human peripheral blood samples were irradiated in vitro with different doses and P-gp activity was analyzed for CD4 and CD8 T lymphocytes through rhodamine123-efflux assay by flow cytometry. By simultaneous employment of percentage and mean fluorescence index parameters, subject-by-subject analysis pointed out changes in P-gp activity for some individuals and irradiated samples. Based on this work, the proposed protocol was considered adequate for evaluating P-gp activity on cells after radioactive stress. Besides, this research suggests that P-gp activity could be an important factor to define patient-specific protocols in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Combined therapy; Radiation effect; P-glycoprotein; Multidrug resistance; Functional analysis; Flow cytometry. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700018 Registros recuperados: 2 Primeira ... 1 ... Última

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