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	Provedor de dados BJMBR (2) Autor Cavalcanti,T.C. (2) Guimarães,F. (2) Rettori,O. (2) Vieira-Matos,A.N. (2) Gregorini,C.C. (1) Vido,A.A. (1) Mais... Palavra-chave Walker 256 tumor (2) Cancer anemia (1) Cancer immunity (1) Hemolytic component (1) Osmotic fragility (1) Plasma fractions (1) RBC osmotic fragility (1) Systemic effects (1) Temporary anemia (1) Tumor regressive variant (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2003 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Changes in red blood cell osmotic fragility induced by total plasma and plasma fractions obtained from rats bearing progressive and regressive variants of the Walker 256 tumor BJMBR Cavalcanti,T.C.; Gregorini,C.C.; Guimarães,F.; Rettori,O.; Vieira-Matos,A.N.. Two variants (A and B) of the widely employed Walker 256 rat tumor cells are known. When inoculated sc, the A variant produces solid, invasive, highly metastasizing tumors that cause severe systemic effects and death. We have obtained a regressive variant (AR) whose sc growth is slower, resulting in 70-80% regression followed by development of immunity against A and AR variants. Simultaneously with the beginning of tumor regression, a temporary anemia developed (~8 days duration), accompanied by marked splenomegaly (~300%) and changes in red blood cell osmotic fragility, with mean corpuscular fragility increasing from 4.1 to 6.5 g/l NaCl. The possibility was raised that plasma factors associated with the immune response induced these changes. In the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Plasma fractions; Temporary anemia; RBC osmotic fragility; Tumor regressive variant; Cancer immunity; Walker 256 tumor. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700009 The hemolytic component of cancer anemia: effects of osmotic and metabolic stress on the erythrocytes of rats bearing multifocal inoculations of the Walker 256 tumor BJMBR Vido,A.A.; Cavalcanti,T.C.; Guimarães,F.; Vieira-Matos,A.N.; Rettori,O.. Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal complications of the illness limit studies of the hemolytic component. A multifocal model of tumor growth was used here to simulate the terminal metastatic dissemination stage (several simultaneous inoculations of Walker 256 cells). The hemolytic component of anemia began 3-4 days after inoculation in 100% of the rats and progressed rapidly thereafter: Hb levels dropped from 14.9 ± 0.02 to 8.7 ± 0.06 from days 7 to 11 (~5 times the physiologically normal rate in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hemolytic component; Cancer anemia; Osmotic fragility; Systemic effects; Walker 256 tumor. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700012 Registros recuperados: 2 Primeira ... 1 ... Última

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