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| Lima,Hawlinston R. C.; Cavalcante-Lima,Haerishton R.; Cedraz-Mercez,Pedro L.; Costa-E-Sousa,Ricardo H.; Olivares,Emerson L.; Badauê-Passos-Jr,Daniel; Medeiros,Magda A.; Côrtes,Wellington S.; Reis,Luís C.. |
| We investigate the influence of brain serotonin depletion on the sodium appetite. Rats depleted of serotonin through the systemic administration of p-chlorophenylalanine (300 mg/kg, ip, for 2 days) showed an intense natriorexigenic response induced by sodium depletion (furosemide, 20 mg/kg, sc, 24 h before water and 1.8% NaCl presentation). Intake of 1.8% NaCl was always higher than that observed for the control group (12.9 ± 1.4 and 21.4 ± 3.0 mL vs 5.7 ± 1.2 and 12.7 ± 1.6 mL, 30 and 300 min after water and saline presentation). After 24 h, the natriorexigenic response continued to be significantly higher compared to control (33.6±5.1 vs 21.9±3.6 mL,P <0.05). Fourteen days after p-chlorophenylalanine administration, 1.8% NaCl intake did not differ... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sodium appetite; Brain serotonin depletion; Sodium and water depletion; Isoproterenol; Serotonergic system. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100008 |
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