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Thyroid cell irradiation by radioiodines: a new Monte Carlo electron track-structure code BABT
Champion,Christophe; Elbast,Mouhamad; Wu,Ting-Di; Colas-Linhart,Nicole.
The most significant impact of the Chernobyl accident is the increased incidence of thyroid cancer among children who were exposed to short-lived radioiodines and 131-iodine. In order to accurately estimate the radiation dose provided by these radioiodines, it is necessary to know where iodine is incorporated. To do that, the distribution at the cellular level of newly organified iodine in the immature rat thyroid was performed using secondary ion mass microscopy (NanoSIMS50). Actual dosimetric models take only into account the averaged energy and range of beta particles of the radio-elements and may, therefore, imperfectly describe the real distribution of dose deposit at the microscopic level around the point sources. Our approach is radically different...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thyroid; Iodine radioisotopes; Monte Carlo simulation; Cellular dosimetry.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600017
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Moving from organ dose to microdosimetry: contribution of the Monte Carlo simulations BABT
Champion,Christophe.
When living cells are irradiated by charged particles, a wide variety of interactions occurs that leads to a deep modification of the biological material. To understand the fine structure of the microscopic distribution of the energy deposits, Monte Carlo event-by-event simulations are particularly suitable. However, the development of these track structure codes needs accurate interaction cross sections for all the electronic processes: ionization, excitation, Positronium formation (for incident positrons) and even elastic scattering. Under these conditions, we have recently developed a Monte Carlo code for electrons and positrons in water, this latter being commonly used to simulate the biological medium. All the processes are studied in detail via...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Electron; Positron; Monte Carlo Simulation; Microdosimetry.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700029
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