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| Andrade,Bruno Horta; Chaves,Miriam Martins; Ribeiro,Angela Maria. |
| A study was conducted to compare health status of male adult Wistar rats from two Experimental Animal Houses of UFMG with literature data of SPF (free from specific pathogens) and conventional rats. The animals were divided into two groups: Group I (n=10), rats from the experimental animal houses of FAFICH and Group II (n=10) from ICB and following aspects were studied: a) evident clinical signs (behavior modification, hair loss (alopecia), b) leukocyte counts, c) feces exam and d) histological study of the lungs. The rats did not show clinical signs. However, when compared with SPF and conventional rats, both the groups showed a significant increase (p<0,05) of leukocyte count. On feces exam we detected some parasites and on lung histological exam we... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Wistar rats; Animal houses; Cellular count. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000300006 |
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| Araújo,Gabrielle Luck de; Campos,Maria Augusta Amaral; Valente,Maria Anete Santana; Silva,Sarah Cristina Teixeira; França,Flávia Dayrell; Chaves,Miriam Martins; Tagliati,Carlos Alberto. |
| Alternative methods are being developed to reduce, refine, and replace (3Rs) animals used in experiments, aimed at protecting animal welfare. The present study reports alternative tests which are based on the principles of the 3Rs and the efforts made to validate these tests. In Europe, several methodologies have already been implemented, such as tests of irritability, cell viability, and phototoxicity as well as in vitro mathematical models together with the use of in silico tools. This is a complex process that spans from development to regulatory approval and subsequent adoption by various official entities. Within this regulatory framework is REACH, the European Community Regulation for chemicals and their safe use. In Brazil, the BraCVAM (Brazilian... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Toxicology/alternative methods; Toxicological analysis/alternative methods; Toxicology/21st; Century; Animals/use in experiments. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100005 |
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