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	Provedor de dados BJMBR (2) Autor Chen,J.Y. (2) Du,C.W. (1) Hong,C.Q. (1) Hong,X. (1) Huang,Z.F. (1) Li,D.R. (1) Lin,Y.C. (1) Lin,Z.Z. (1) Peng,X. (1) Wen,B.G. (1) Wu,M.Y. (1) Xie,L.X. (1) Yang,L.X. (1) Zhang,H. (1) Mais... Palavra-chave Arsenic trioxide (As2O3) (1) Latent membrane protein 1 (1) Metalloproteinase 9 (1) Metastases (1) Nasopharyngeal carcinoma (1) Nuclear localization (1) Nuclear localization signal (NLS) (1) Siva-1 (1) Subcellular compartmentalization (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization BJMBR Chen,J.Y.; Yang,L.X.; Huang,Z.F.. Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions. Although many studies have demonstrated that Siva-1 functions in the cytoplasm, a few have found that Siva-1 can relocate to the nucleus. In this study, we found that the first 33 amino acid residues of Siva-1 are required for its nuclear localization. Further study demonstrated that the green fluorescent protein can be imported into the nucleus after fusion with these 33 amino acid residues. Other Siva-1 regions and domains showed less effect on Siva-1 nuclear localization. By site-mutagenesis of all of these 33 amino acid residues, we found that mutants of the first 1-18 amino acids... Tipo: Info:eu-repo/semantics/article Palavras-chave: Siva-1; Nuclear localization signal (NLS); Subcellular compartmentalization; Nuclear localization. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201021 Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro BJMBR Du,C.W.; Wen,B.G.; Li,D.R.; Peng,X.; Hong,C.Q.; Chen,J.Y.; Lin,Z.Z.; Hong,X.; Lin,Y.C.; Xie,L.X.; Wu,M.Y.; Zhang,H.. Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. Then, can it repress the cancer cells' metastasis potential? To elucidate this issue, the present study was performed. LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. Cells (1 x 10(5)/mL) were cultured with or without 3 µM As2O3 for 48 h. Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. Both confocal immunofluorescence staining and Western blot were used to detect the changes... Tipo: Info:eu-repo/semantics/article Palavras-chave: Arsenic trioxide (As2O3); Nasopharyngeal carcinoma; Metastases; Latent membrane protein 1; Metalloproteinase 9. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500015 Registros recuperados: 2 Primeira ... 1 ... Última

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