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	Provedor de dados BJMBR (1) Genet. Mol. Biol. (1) Autor Chen,Zhe (2) Chen,Zhao-Hui (1) Guo,Xiaoling (1) Jiang,Tao (1) Jiang,Xiaoling (1) Lv,Zunzhou (1) Tan,Dan (1) Xu,Ningying (1) Zhao,Xiaofeng (1) Zhou,Hongmei (1) Mais... Palavra-chave Apoptosis (1) Carcass and meat quality (1) Cervical cancer (1) ERK/AKT (1) Haplotype (1) PPARγ2 gene (1) Pigs (1) Proliferation (1) SULF2 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway BJMBR Jiang,Tao; Chen,Zhao-Hui; Chen,Zhe; Tan,Dan. The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa cells were divided into six groups: control group, NC group, SULF2 siRNA group, SULF2 group, SULF2 + LY294002 group, and SULF2 + U0125 group. In each group, HeLa cells received the corresponding treatment, followed by measurement of the cellular biological characteristics and expression of the ERK/AKT signaling pathway. We also confirmed the effect of SULF2 in vivo using a xenograft model in nude mice. SULF2 was upregulated in cervical cancer tissues, which was specifically associated with the clinical stage, histological... Tipo: Info:eu-repo/semantics/article Palavras-chave: SULF2; Cervical cancer; ERK/AKT; Proliferation; Apoptosis. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000200608 Association of PPARγ2 polymorphisms with carcass and meat quality traits in a Pietrain x Jinhua F2 population Genet. Mol. Biol. Chen,Zhe; Zhao,Xiaofeng; Jiang,Xiaoling; Guo,Xiaoling; Lv,Zunzhou; Zhou,Hongmei; Xu,Ningying. The PPARγ2 gene is a key regulator of both proliferation and preadipocyte differentiation in mammals. Herein its genotype and allele frequencies were analyzed using PCR-SSCP in eight pig breeds (N = 416). Two kinds of polymorphisms of the PPARγ2 gene were detected, including a previously reported shift SNP A177G (Met59Val) in exon 1 and a novel silent mutation G876A in exon 5. The results revealed that European pig breeds carry a higher allele A frequency at the A177G locus and a fixed GG genotype at the G876A locus. Allele A at the G876A locus was only found in Jinhua pigs. The association between haplotype (A177G/G876A) and carcass and meat quality traits was analyzed in a Pietrain x Jinhua F2 population (N = 248). The PPARγ2 gene was found to be... Tipo: Info:eu-repo/semantics/article Palavras-chave: PPARγ2 gene; Haplotype; Carcass and meat quality; Pigs. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100011 Registros recuperados: 2 Primeira ... 1 ... Última

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