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Evaluation of drive mechanisms (including transgenes and drivers) in different environmental conditions and genetic backgrounds Frontis
James, A.A.; Benedict, M.Q.; Christophides, G.K.; Jacobs-Lorena, M.; Olson, K.E..
Three major objectives, develop viable gene drive mechanisms, identify the epidemiologically significant vectors of pathogens in specific transmission zones, and introgress effector genes into specific populations, must be met in order to move to the field laboratory advances in genetic control strategies
Tipo: Conference proceedings
Ano: 2005 URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1193
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What are relevant assays for refractoriness? Frontis
Christophides, G.K.; Gouagna, L.C.; Jacobs-Lorena, M.; James, A.A.; Olson, K.E..
The engineering and testing of genes that result in refractory phenotypes are important components of the continuing effort towards the use of population replacement strategies for vector control. Both ‘endogenous’ and ‘synthetic’ refractory phenotypes are being considered. Additional research is required to determine the prevalence of such phenotypes in the various vector–pathogen combinations, and the threshold levels of activity of genes conferring transmission blocking, as well as to develop efficient methods for the evaluation of their entire spectrum of biological effects
Tipo: Conference proceedings
Ano: 2005 URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1195
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