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| Nascimento,Wenna Gleyce Araújo do; Cilião,Daiani Alves; Genre,Julieta; Gondim,Dikson Dibe; Alves,Renata Gomes; Hassan,Neife Deghaide; Lima,Francisco Pignataro; Pereira,Maurício Galvão; Donadi,Eduardo Antônio; Crispim,Janaina Cristiana de Oliveira. |
| Interleukin 18 (IL-18) is a proinflammatory cytokine that plays a role in host defense by upregulating both innate and acquired immune responses. Analysis of IL 18 polymorphisms may be clinically important since their roles have been recognized in a variety of inflammatory and autoimmune disorders. However, the role of this cytokine polymorphisms in kidney transplant still remains unclear. In this study, we evaluated the associations between IL 18 polymorphisms and graft function assessed by creatinine clearance in kidney transplant recipients. A total of 82 kidney transplant recipients and 183 healthy controls were enrolled, and frequencies of alleles, genotypes and haplotypes for IL 18 polymorphisms were determined and compared with creatinine clearance.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: IL-18; -607C/A; -137C/G; Kidney transplant. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300005 |
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