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	Provedor de dados Nature Precedings (2) Autor Claire Williamson (2) Donald C. Cooper (2) Kami Wenzel (2) Abby Drish (1) Bridget Deeney (1) Bridget Deeney (1) Eric Ostertag (1) Eric Ostertag (1) Jessica Stumme (1) Laura Swenson (1) Marissa Collins (1) Phuong Nguyen (1) Phuong Nguyen (1) William D. Klipec (1) William D. Klipec (1) Mais... Palavra-chave Neuroscience (2) Genetics & Genomics (1) Pharmacology (1) Tipo do documento Manuscript (2) Ano 2012 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Deletion of the rat trpc4 gene and its influence on motivated responding for natural reward Nature Precedings William D. Klipec; Bridget Deeney; Claire Williamson; Kami Wenzel; Phuong Nguyen; Eric Ostertag; Donald C. Cooper. TRPC4 ion channels are expressed extensively in corticolimbic brain regions and a subpopulation of midbrain dopamine neurons. TRPC4 knockout (KO) rats show reduced sociability and social exploration, but show no differences in simple and complex strategic learning compared to normal wild type (WT) rats. Using water reward, we found no differences between TRPC4-KO and WT rats in the break point on a progressive ratio schedule of reinforcement. Although deletion of the trpc4 gene alters social interaction/anxiety it does not appear to affect motivation for natural rewards. Current experiments are underway testing the role of trpc4 gene deletion on cocaine reward (see www.neuro-cloud.net/nature-precedings/klipec3 for updates and collaborations). Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience. Ano: 2012 URL: http://precedings.nature.com/documents/7109/version/1 Deletion of the trpc4 gene and its role in simple and complex strategic learning Nature Precedings William D. Klipec; Phuong Nguyen; Bridget Deeney; Claire Williamson; Kami Wenzel; Jessica Stumme; Marissa Collins; Abby Drish; Laura Swenson; Eric Ostertag; Donald C. Cooper. The TRPC4 ion channel is expressed extensively in corticolimbic and a subpopulation of midbrain dopamine neurons. While TRPC4 knockout (KO) rats exhibit reduced sociability and social exploration, little is known about the role of TRPC4 in motivation and learning. To identify a function for TRPC4 channels in learning processes  we tested TRPC4 KO and normal wild type (WT) rats. TRPC4 KO and WT rats exhibited no differences in Y-­maze learning or simple discrimination learning. Furthermore, on a more complex serial reversal shift task designed  to assess strategic learning where the reward and non-­reward cues were repeatedly reversed between training sessions both TRPC4 KO and WT rats  ... Tipo: Manuscript Palavras-chave: Neuroscience; Pharmacology. Ano: 2012 URL: http://precedings.nature.com/documents/6929/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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