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| Cocca,Claudia; Ventura,Clara; Nunez,Mariel; Randi,Andrea; Venturino,Andres. |
| El clorpirifos (CPF) es un insecticida de amplio espectro que se utiliza en Argentina y en otros países de Latinoamérica. Se emplea para el control de plagas en la producción de frutas, hortalizas, cereales y plantas ornamentales. El principal mecanismo de acción descripto para este insecticida es la inhibición de la acetilcolinesterasa. Sin embargo, reportes más recientes sugieren múltiples efectos del plaguicida independientes de la inhibición de esa enzima. El objetivo de este trabajo es transmitir a la comunidad los resultados de nuestras investigaciones obtenidos utilizando diferentes dosis de CPF en distintos modelos experimentales, tanto in vitro como in vivo. En relación a esto, hemos evidenciado una acción del CPF sobre el sistema redox celular... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Clorpirifos; Cáncer de mama; Estradiol; ERO. |
| Ano: 2015 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432015000300005 |
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| Mohamad,Nora; Gutiérrez,Alicia; Núñez,Mariel; Cocca,Claudia; Martín,Gabriela; Cricco,Graciela; Medina,Vanina; Rivera,Elena; Bergoc,Rosa. |
| Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution of PCD includes the release of several proapoptotic proteins from the intermembrane space of mitochondria. They could exert their actions through a caspase dependent as well as a caspase independent way. On the other hand, regulation of PCD is mainly given by the Bcl-2 family members, which are in turn essentially regulated by activation of death receptors and/or DNA... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apoptosis; Mitochondria; Bcl-2 family; Cytochrome-c. |
| Ano: 2005 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452005000200001 |
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