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Pseudotumoral form of primary progressive tuberculosis: a diagnosis to be considered BJID
Franco,Rosana; Santana,Maria Angélica; Coelho Filho,João Carlos; Pereira-Silva,Jorge L..
The diversity of clinical presentations of primary progressive tuberculosis (TB) and the difficulty in establishing the diagnosis of paucibacillary forms is the subject of painstaking research, as well as a cause of delay in therapy. We report the case of a 10-year-old black child who presented with chest pain and progressive widening of the upper mediastinum. Computerized tomography of the chest revealed multiple calcifications that were not identified with X-rays. Biopsy through mediastinoscopy was compatible with a diagnosis of tuberculosis. Despite exhaustive investigation that included direct examination, culture for mycobacteria and PCR (Polymerase Chain Reaction) of tissue samples, the etiologic agent was not revealed. Tuberculin conversion was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lymph node tuberculosis; Pseudotumoral form; Diagnosis.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000200011
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Revisiting the Rich's formula: an update about granulomas in human tuberculosis BJID
Coelho Filho,João Carlos; Takenami,Iukary; Arruda,Sérgio.
The formula proposed by Rich in 1951 explained the formation in a tuberculous lesion in a period that was unknown cellular functions, cytokines and other immunological aspects involved in granuloma formation by tuberculosis; its components are assembled conceptually to explain the pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. In this manuscript, we report an update of Rich's formula based on the new and old concepts about pathogenic mechanisms involved in the granulomatous lesion in tuberculosis. Current knowledge allows us to conclude that the balance between the characteristics of the bacillus and host protective response is necessary to indicate the outcome of pathogenesis, infection or active disease and the necrosis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rich's formula; Tuberculosis; Immunopathogenesis; Granuloma; Hypersensitivity.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200017
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