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	Provedor de dados BJMBR (3) Autor Coimbra,N.C. (3) Biagioni,A.F. (1) Castro-Souza,C. (1) Ferreira,S.H. (1) Medeiros,A.C. (1) Medeiros,P. (1) Morato,S. (1) Segato,E.N. (1) Segato,F.N. (1) Silva,J.A. (1) da Silva,J.A. (1) de Freitas,R.L. (1) dos Santos,I.R. (1) Mais... Palavra-chave Antinociception (1) Chronic constriction injury of the nervus ischiadicus (1) Dorsomedial hypothalamus (1) Endogenous opioids (1) Fear-induced antinociception (1) Indomethacin (1) Mechanical allodynia (1) Naloxone (1) Neuropathic pain (1) Non-steroidal anti-inflammatory drugs (1) Panic-like behavior (1) Posterior hypothalamus (1) Rats (1) Sucrose intake (1) Tail-flick test (1) Von Frey test (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2012 (1) 1997 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury BJMBR Medeiros,P.; dos Santos,I.R.; Medeiros,A.C.; da Silva,J.A.; Ferreira,S.H.; de Freitas,R.L.; Coimbra,N.C.. The neurochemical mechanisms underlying neuropathic pain (NP) are related to peripheral and central sensitization caused by the release of inflammatory mediators in the peripheral damaged tissue and ectopic discharges from the injured nerve, leading to a hyperexcitable state of spinal dorsal horn neurons. The aim of this work was to clarify the role played by cyclooxygenase (COX) in the lesioned peripheral nerve in the development and maintenance of NP by evaluating at which moment the non-steroidal anti-inflammatory drug indomethacin, a non-selective COX inhibitor, attenuated mechanical allodynia after placing one loose ligature around the nervus ischiadicus, an adaptation of Bennett and Xie's model in rodents. NP was induced in male Wistar rats by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Non-steroidal anti-inflammatory drugs; Indomethacin; Chronic constriction injury of the nervus ischiadicus; Neuropathic pain; Mechanical allodynia; Von Frey test. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500606 Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae) BJMBR Biagioni,A.F.; Silva,J.A.; Coimbra,N.C.. The hypothalamus is a forebrain structure critically involved in the organization of defensive responses to aversive stimuli. Gamma-aminobutyric acid (GABA)ergic dysfunction in dorsomedial and posterior hypothalamic nuclei is implicated in the origin of panic-like defensive behavior, as well as in pain modulation. The present study was conducted to test the difference between these two hypothalamic nuclei regarding defensive and antinociceptive mechanisms. Thus, the GABA A antagonist bicuculline (40 ng/0.2 µL) or saline (0.9% NaCl) was microinjected into the dorsomedial or posterior hypothalamus in independent groups. Innate fear-induced responses characterized by defensive attention, defensive immobility and elaborate escape behavior were evoked by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Panic-like behavior; Fear-induced antinociception; Dorsomedial hypothalamus; Posterior hypothalamus. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400007 Sucrose ingestion causes opioid analgesia BJMBR Segato,F.N.; Castro-Souza,C.; Segato,E.N.; Morato,S.; Coimbra,N.C.. The intake of saccharin solutions for relatively long periods of time causes analgesia in rats, as measured in the hot-plate test, an experimental procedure involving supraspinal components. In order to investigate the effects of sweet substance intake on pain modulation using a different model, male albino Wistar rats weighing 180-200 g received either tap water or sucrose solutions (250 g/l) for 1 day or 14 days as their only source of liquid. Each rat consumed an average of 15.6 g sucrose/day. Their tail withdrawal latencies in the tail-flick test (probably a spinal reflex) were measured immediately before and after this treatment. An analgesia index was calculated from the withdrawal latencies before and after treatment. The indexes (mean ± SEM, N =... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antinociception; Sucrose intake; Tail-flick test; Endogenous opioids; Rats; Naloxone. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800011 Registros recuperados: 3 Primeira ... 1 ... Última

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