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| Peixoto,T.C.; Moura,E.G.; Oliveira,E.; Younes-Rapozo,V.; Soares,P.N.; Rodrigues,V.S.T.; Santos,T.R.; Peixoto-Silva,N.; Carvalho,J.C.; Calvino,C.; Conceição,E.P.S.; Guarda,D.S.; Claudio-Neto,S.; Manhães,A.C.; Lisboa,P.C.. |
| Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction is related to obesity, here we tested the hypothesis that higher levels of thyroid hormones are not functional in BAT, suggesting a lower metabolic rate. We evaluated autonomic nerve activity in BAT and its function in adult rats that were exposed to tobacco smoke during lactation. At birth, litters were adjusted to 3 male and 3 female pups/litter. From postnatal day (PND) 3 to 21, Wistar lactating rats... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tobacco smoke Suckling period Developmental plasticity; Obesity Autonomic function. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600602 |
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| de Oliveira,E.; Lima,N.S.; Conceição,E.P.S.; Peixoto-Silva,N.; Moura,E.G.; Lisboa,P.C.. |
| Early weaning (EW) leads to overweight, visceral obesity, hyperleptinemia, and insulin resistance in adulthood. Treatment with Ilex paraguariensis (yerba mate) improves obesity and insulin resistance in these animals. Here, we evaluated the effects of chronic treatment with yerba mate on the redox balance and liver morphology of overweight early-weaned rats. To induce EW, we wrapped the dams with bandages to interrupt milk access during the last 3 days of lactation. Control pups (C) had free access to maternal milk for the full 21 days of lactation. On postnatal day (PN) 150, EW offspring were subdivided into the EW+YM group, which received the aqueous extract of yerba mate (1 g/kg bw by gavage once a day for 30 days) and the EW group, which received water... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Early weaning; Programming; Oxidative stress; Steatosis; Liver. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600619 |
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