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	Provedor de dados Biol. Res. (2) Autor Conget,Paulette (2) Calligaris,Sebastián D (1) Encina,Gonzalo (1) Ezquer,Fernando (1) Israel,Yedy (1) Palavra-chave Cardiac function (1) Diabetic cardiomyopathy (1) Dobutamine (1) Gastrointestinal enteroendocrine cells (1) K-cells (1) L-cells (1) Metabolic syndrome (1) Multipotent mesenchymal stromal cells (1) Obesity (1) Preproinsulin gene (1) Type 1 diabetes mellitus (1) Mais... Tipo do documento Journal article (2) Ano 2013 (1) 2011 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene Biol. Res. Encina,Gonzalo; Ezquer,Fernando; Conget,Paulette; Israel,Yedy. Transgenic mice carrying the human insulin gene driven by the K-cell glucose-dependent insulinotropic peptide (GIP) promoter secrete insulin and display normal glucose tolerance tests after their pancreatic p-cells have been destroyed. Establishing the existence of other types of cells that can process and secrete transgenic insulin would help the development of new gene therapy strategies to treat patients with diabetes mellitus. It is noted that in addition to GIP secreting K-cells, the glucagon-like peptide 1 (GLP-1) generating L-cells share/ many similarities to pancreatic p-cells, including the peptidases required for proinsulin processing, hormone storage and a glucose-stimulated hormone secretion mechanism. In the present study, we demonstrate that... Tipo: Journal article Palavras-chave: Type 1 diabetes mellitus; Preproinsulin gene; Gastrointestinal enteroendocrine cells; K-cells; L-cells. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300012 Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells has a neutral effect on obesity-induced diabetic cardiomyopathy Biol. Res. Calligaris,Sebastián D; Conget,Paulette. Obesity is a major global health issue. Obese patients develop metabolic syndrome, which is a cluster of clinical features characterized by insulin resistance and dyslipidemia. Its cardiac manifestation, diabetic cardiomyopathy, leads to heart failure. Bone marrow-derived multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSC) are envisioned as a therapeutic tool not only for cardiovascular diseases but also for other degenerative conditions. Our aim was to evaluate whether the intravenous administration of MSC modifies cardiac dysfunction in obese mice. To this end, C57BL/6 mice were fed a regular (normal) or high-fat diet (obese). Obese animals received the vehicle (obese), a single dose (obese + 1x MSC) or three doses... Tipo: Journal article Palavras-chave: Obesity; Metabolic syndrome; Diabetic cardiomyopathy; Multipotent mesenchymal stromal cells; Cardiac function; Dobutamine. Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000300005 Registros recuperados: 2 Primeira ... 1 ... Última

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