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| Baby,André Rolim; Lacerda,Áurea Cristina Lemos; Sarruf,Fernanda Daud; Pinto,Claudinéia Aparecida Sales de Oliveira; Consiglieri,Vladi Olga; Serra,Cristina Helena dos Reis; Velasco,Maria Valéria Robles; Kawano,Yoshio; Kaneko,Telma Mary. |
| Recently, there has been an interest in the use of shed snake skin as alternative model biomembrane for human stratum corneum. This research work presented as objective the qualitative characterization of alternative model biomembranes from Bothrops jararaca and Spilotis pullatus by FT-Raman, PAS-FTIR and DSC. The employed biophysical techniques permitted the characterization of the biomembranes from shed snake skin of B. jararaca and S. pullatus by the identification of vibrational frequencies and endothermic transitions that are similar to those of the human stratum corneum. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biomembrane/alternative models; Bothrops jararaca/skin; Bothrops jararaca/qualitative characterization; Spilotis pullatus/skin; Spilotis pullatus/qualitative characterization; Human stratum corneum/similars. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300006 |
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| Monteiro,Lis Marie; Tavares,Guilherme Diniz; Ferreira,Elizabeth Igne; Consiglieri,Vladi Olga; Bou-Chacra,Nadia Araci; Löbenberg,Raimar. |
| Hydroxymethylnitrofurazone (NFOH) is a new compound with potential leishmanicidal and trypanocidal activity. Despite its effectiveness, the formulators have to overcome its poor aqueous solubility. Recently, polymeric nano-scale drug delivery systems have proposed for the treatment of neglected diseases. As several studies have confirmed the advantages of such formulations, and this approach provides new analytical challenges, including the need to detect trace amounts of the drug. A suitable method was developed and validated for NFOH determination bound to poly (n-butylcyanoacrylate) (PBCA) nanoparticles. The chromatographic separation was achieved using a C18 column maintained at 25 ºC and an isocratic mobile phase consisting of water and acetonitrile:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hydroxymethylnitrofurazone/determinação; Nanoparticle; High-performance liquid chromatography/reverse phase/quantitative analysis; Poly(n-butylcyanoacrylate)/nanoparticles/encapsulation. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300561 |
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| Consiglieri,Vladi Olga; Mourão,Samanta; Sampaio,Mauricio; Granizo,Patricia; Garcia,Pedro; Martinello,Valeska; Spricigo,Rodrigo; Ferraz,Humberto Gomes. |
| The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluconazole/flowability; Tablets/dissolution; Capsules/dissolution; Plasdone. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100013 |
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| Prestes,Paula Souza; Peres,Daniela D'Almeida; Freitas,Anderson Zanardi de; Consiglieri,Vladi Olga; Kaneko,Telma Mary; Velasco,Maria Valéria Robles; Baby,André Rolim. |
| ABSTRACT The physicochemical attributes of emulsified systems are influenced by the characteristics of their internal phase droplets (concentration, size and morphology), which can be modified not only by the formulation components, but also by the analytical methodology employed. Thus, the aim of this work involved the physicochemical characterization of cosmetic emulsions obtained from different surfactants, as well as the introduction of the optical coherence tomography (OCT) as the analytical technique employed for the morphological characterization and particle size determination of the formulations. Three emulsions were prepared, differing at the type and concentration of the surfactant used, and their droplet sizes were evaluated through optical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cosmetic emulsions/physicochemical characterization; Surfactants; Optical coherence tomography/morphological characterization; Optical microscopy/morphological characterization; Laser diffraction/morphological characterization. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200273 |
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| Graziola,Fabiana; Candido,Thalita Marcílio; Oliveira,Camila Areias de; Peres,Daniela D'Almeida; Issa,Michele Georges; Mota,Joana; Rosado,Catarina; Consiglieri,Vladi Olga; Kaneko,Telma Mary; Velasco,Maria Valéria Robles; Baby,André Rolim. |
| ABSTRACT Glutaraldehyde (GTA) has been extensively used as a gelatin crosslinking agent, however, new natural ones have been suggested as more biocompatible. Polyphenols are possible candidates and the flavonols, such as rutin (RUT), also exhibit potential synergism with sunscreens and antioxidant agents used in cosmetics. In this work, gelatin microspheres (M0) were obtained and crosslinked with GTA 10 mM (MG) or RUT 10 mM (MR), dissolved in acetone:NaOH 0,01M (70:30 v/v). MG exhibited crosslinking extent of 54.4%. Gelatin, M0, MG and MR did not elicit any signs of skin damage, regarding the formation of erythema, the barrier function disruption and negative interference in the stratum corneum hydration. Oily dispersions containing M0, MG or MR, isolated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protection solar/tests; Gelatin/microspheres/safety testing; Glutaraldehyde/safety testing; Flavonoids/Rutin/use in cosmetics; Natural products/use in cosmetics.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400603 |
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| Silva,Débora Granemann e; Sarruf,Fernanda Daud; Oliveira,Larissa Carolina Diniz de; Arêas,Elizabeth Pinheiro Gomes; Kaneko,Telma Mary; Consiglieri,Vladi Olga; Velasco,Maria Valéria Robles; Baby,André Rolim. |
| Nanotechnology applies to diverse sectors of science. In cosmetic area, investments have strengthened the idea that nanoproducts provide innumerable benefits to consumers. Extreme exposition to solar light can cause undesirable effects, thus, adding UV filters in cosmetic products are often used as prevention. Ethylhexyl methoxycinnamate and benzophenone-3 are UV filters widely used in sunscreen formulations, this UV filters absorb UVB and UVA radiation, respectively. In this study, sunscreen formulations were developed as nano and macroemulsion, but composed by the same raw material. Nanoemulsion was obtained by phase inversion temperature method (PIT). Physical and functional properties were evaluated by visual analysis, particle size distribution and by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Nanoemulsion; PIT method; Benzophenone-3; Ethylhexyl methoxycinnamate. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200007 |
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| Vieira,Rafael Pinto; Fernandes,Alessandra Ribeiro; Kaneko,Telma Mary; Consiglieri,Vladi Olga; Pinto,Claudinéia Aparecida Sales de Oliveira; Pereira,Claudia Silva Cortez; Baby,André Rolim; Velasco,Maria Valéria Robles. |
| Peel off facial masks, based on polyvinyl alcohol (PVA), are formulations that, after application and drying, form an occlusive film over the face. After removing, they provide cleanness, tensor and moisturizing effects, removing dead cells, residues and other materials deposited on the stratum corneous. The soybean extract fermented by Bifidobacterium animalis has sugars, amino acids, peptides, proteins and free isoflavonoids in high concentrations, when compared to the unfermented extract, providing benefits to the cosmetic formulations like anti-aging effect, moisture, tensor action and emollience. The cosmetic bases of peel off facial masks, added with 5.0% w/w of fermented soybean extract, were submitted to Preliminary and Accelerated Stability... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cosmetic formulations/physical and physicochemical stability; Facial mask peel off; Polyvinyl alcohol; Soybean extract; Bifidobacterium animalis/fermentation. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300018 |
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| Peres,Daniela D'Almeida; Hubner,Alexandra; Oliveira,Camila Areias de; Almeida,Tania Santos de; Kaneko,Telma Mary; Consiglieri,Vladi Olga; Pinto,Claudinéia Aparecida Sales de Oliveira; Velasco,Maria Valéria Robles; Baby,André Rolim. |
| ABSTRACT The chronological skin aging is a progressive and natural process with genetic and physiological changes. However, ultraviolet (UV) radiation may accelerate the oxidative stress, generating carcinogenesis and photoaging. Natural compounds and their applications are considered a trend in the cosmetic market. The protein-based film-forming compounds play an important role, once it collaborates for the better distribution of sunscreens on the skin. Here we investigated the in vitro photoprotective effectiveness of sunscreens containing the hydrolyzed collagen associated with UVA, UVB and/or inorganic filters. Sunscreens were developed with octocrylene (7.5%), butyl methoxydibenzoylmethane (avobenzone) (3.0%) and/or titanium dioxide (5.0%), associated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hydrolyzed collagen/protective effects; Photoprotector/effectiveness; Photoprotector/in vitro study; Sun protection factor; Sunscreen/UV filter; Critical wavelength. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200611 |
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