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Autonomic abnormalities demonstrable in young normotensive subjects who are children of hypertensive parents BJMBR
Lopes,H.F.; Silva,H.B.; Consolim-Colombo,F.M.; Barreto Filho,J.A.S.; Riccio,G.M.G.; Giorgi,D.M.A.; Krieger,E.M..
Although a slightly elevated office blood pressure (BP) has been reported in several studies, little is known about the prolonged resting blood pressure, heart rate (HR) and baroreflex sensitivity (BRS) of prehypertensive subjects with a family history of hypertension. Office blood pressure, prolonged resting (1 h) BP and HR were measured in 25 young normotensives with a positive family history of hypertension (FH+) and 25 young normotensives with a negative family history of hypertension (FH-), matched for age, sex, and body mass index. After BP and HR measurements, blood samples were collected for the determination of norepinephrine, plasma renin activity and aldosterone levels, and baroreflex sensitivity was then tested. Casual BP, prolonged resting BP...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart rate; Blood pressure; Baroreflex sensitivity; Family history of hypertension.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100007
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Increased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parents BJMBR
Lopes,H.F.; Consolim-Colombo,F.M.; Barreto-Filho,J.A.S.; Riccio,G.M.G.; Negrão,C.E.; Krieger,E.M..
Malignant hypertension seems to be the consequence of very high blood pressure. Furthermore, an increase in sympathetic and renin-angiotensin system activity is considered to be the main mechanisms producing malignant hypertension. In the present study, 10 offspring of malignant hypertensive (OMH) parents (age 28 ± 5 years, 7 males, 3 females, 2 white and 8 non-white) and 10 offspring of normotensive (ONT) parents (age 28 ± 6 years, 2 males, 8 females, 3 white and 7 non-white) were evaluated. The OMH group had significantly higher (P < 0.05) casual blood pressure (125 ± 10/81 ± 5 mmHg) compared with ONT (99 ± 13/67 ± 5 mmHg). The increase in blood pressure was greater in OMH (Δ SBP = 17 ± 2 vs Δ SBP = 9 ± 1 mmHg in ONT) during cold pressor testing, but...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Malignant hypertension; Offspring of malignant hypertensive parents; Sympathetic activity; Microneurography.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000003
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Pressure and time dependence of the cardiopulmonary reflex response in patients with hypertensive cardiomyopathy BJMBR
Otto,M.E.B.; Consolim-Colombo,F.M.; Rodrigues Sobrinho,C.R.M.; Krieger,E.M..
The first minutes of the time course of cardiopulmonary reflex control evoked by lower body negative pressure (LBNP) in patients with hypertensive cardiomyopathy have not been investigated in detail. We studied 15 hypertensive patients with left ventricular dysfunction (LVD) and 15 matched normal controls to observe the time course response of the forearm vascular resistance (FVR) during 3 min of LBNP at -10, -15, and -40 mmHg in unloading the cardiopulmonary receptors. Analysis of the average of 3-min intervals of FVR showed a blunted response of the LVD patients at -10 mmHg (P = 0.03), but a similar response in both groups at -15 and -40 mmHg. However, using a minute-to-minute analysis of the FVR at -15 and -40 mmHg, we observed a similar response in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Baroreflex; Essential hypertension; Heart failure; Cardiopulmonary reflex; Baroreceptors.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100004
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Critical analysis of autoregressive and fast Fourier transform markers of cardiovascular variability in rats and humans BJMBR
Silva,G.J.J.; Ushizima,M.R.; Lessa,P.S.; Cardoso,L.; Drager,L.F.; Atala,M.M.; Consolim-Colombo,F.M.; Lopes,H.F.; Cestari,I.A.; Krieger,J.E.; Krieger,E.M..
The autonomic nervous system plays an important role in physiological and pathological conditions, and has been extensively evaluated by parametric and non-parametric spectral analysis. To compare the results obtained with fast Fourier transform (FFT) and the autoregressive (AR) method, we performed a comprehensive comparative study using data from humans and rats during pharmacological blockade (in rats), a postural test (in humans), and in the hypertensive state (in both humans and rats). Although postural hypotension in humans induced an increase in normalized low-frequency (LFnu) of systolic blood pressure, the increase in the ratio was detected only by AR. In rats, AR and FFT analysis did not agree for LFnu and high frequency (HFnu) under basal...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fast Fourier transform; Autoregressive model; Hypertension; SHR; Pharmacological blockade; Tilt test.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400012
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