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| Barichello,T.; Martins,M.R.; Reinke,A.; Constantino,L.S.; Machado,R.A.; Valvassori,S.S.; Moreira,J.C.F.; Quevedo,J.; Dal-Pizzol,F.. |
| Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50% of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in sepsis-surviving rats. One hundred and ten male Wistar rats (3-4 months, 250-300 g) were submitted to cecal ligation and puncture (CLP), and 44 were submitted to sham operation. Forty-four rats (40%) survived after CLP, and all sham-operated animals survived and were used as control. Twenty animals of each group were used in the object recognition task (10 in short-term memory and 10 in long-term memory),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis survivors; Recognition memory; Plus-maze test; Forced swimming test; Cecal ligation and puncture; Cognitive impairment. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600013 |
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