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| Ospina Medina,Luisa; Álvarez Gómez,Ángela; Cortés Mancera,Fabian; Cadavid Jaramillo,Ángela; Cardona Maya,Walter. |
| Introduction: there are natural products from different fruits and plants that are effective as spermicides, but it is important that they should have little or no cytotoxic effect on epithelial cells. Currently available spermicides with nonoxynol-9 cause vaginal irritation and damage to the vaginal mucosa, the uterine epithelium, and the microbial flora of the vagina. Objective: to elucidate the effect on cell viability, cytotoxicity and apoptosis of spermicidal extracts of Ananas comosus (L.) Merr. and Sapindus saponaria L. over HeLa cell line. Methods: both extracts were evaluated on HeLa cell line using the novel ApoTox-Glo™ Triplex Assay to determine whether cell viability, cytotoxicity and apoptosis were affected. Results: it was... |
| Tipo: Journal article |
Palavras-chave: Natural compounds; Spermicides; Cell cytotoxicity; Cell viability; Cell apoptosis; Ananas comosus; Sapindus saponaria. |
| Ano: 2013 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000400005 |
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