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	Provedor de dados BJMBR (1) Autor Cortellazzi,L.C. (1) Grotto,H.Z.W. (1) Teixeira,S.M. (1) Palavra-chave Fetal hemoglobin (1) Gamma chain (1) Hydroxyurea (1) Sickle-cell disease (1) Tipo do documento Info:eu-repo/semantics/other (1) Ano 2003 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Effect of hydroxyurea on G gamma chain fetal hemoglobin synthesis by sickle-cell disease patients BJMBR Teixeira,S.M.; Cortellazzi,L.C.; Grotto,H.Z.W.. Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis and consequently decrease the severity of pain episodes. Fetal hemoglobin, which is formed by gamma-globin chains A and G, is present in a constant composition throughout fetal development: about 75% of Ggamma and 25% of Agamma. In contrast, adult red cells contain about 40% of Ggamma and 60% of Agamma. In the present study, we analyzed the effect of hydroxyurea induction on the gamma chain composition of fetal hemoglobin in 31 sickle-cell disease patients treated with hydroxyurea. The control group was composed of 30 sickle-cell disease patients not treated with hydroxyurea in clinical steady state. The patients were older than 13 years and were not... Tipo: Info:eu-repo/semantics/other Palavras-chave: Gamma chain; Fetal hemoglobin; Hydroxyurea; Sickle-cell disease. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000002 Registros recuperados: 1 Primeira ... 1 ... Última

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