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| Silva,Flavia Rodrigues da; Paiva,Mayara Rodrigues Brandão de; Dourado,Lays Fernanda Nunes; Silva,Rummenigge Oliveira; Silva,Carolina Nunes da; Costa,Bruna Lopes da; Toledo,Cibele Rodrigues; Lima,Maria Elena de; Silva-Cunha,Armando da. |
| Abstract Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion channels including those present in the ocular system. To study potential toxicity and safety of intravitreal injection in rabbits of LyeTx I b, a synthetic peptide derived from the toxin LyeTx I found in venom from the spider Lycosa eritrognatha and to evaluate the angiogenic activity on a CAM model. Methods: ARPE-19 cells were treated with LyeTx I b (0.36; 0.54; 0.72; 2.89; 4.34 or 9.06 μM). In this study, New Zealand rabbits were used. LyeTx I b (2.89 μM) labeled with FITC dissolved in PBS, or only PBS, were injected into... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lycosa eritrognatha; LyeTx I b; Intravitreal injection; Retinal diseases; Toxicity; Retinal neovascularization. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100322 |
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