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| Vigo,A.; Duncan,B.B.; Schmidt,M.I.; Couper,D.; Heiss,G.; Pankow,J.S.; Ballantyne,C.M.. |
| To efficiently examine the association of glutamic acid decarboxylase antibody (GADA) positivity with the onset and progression of diabetes in middle-aged adults, we performed a case-cohort study representing the ~9-year experience of 10,275 Atherosclerosis Risk in Communities Study participants, initially aged 45-64 years. Antibodies to glutamic acid decarboxylase (GAD65) were measured by radioimmunoassay in 580 incident diabetes cases and 544 non-cases. The overall weighted prevalence of GADA positivity (³1 U/mL) was 7.3%. Baseline risk factors, with the exception of smoking and interleukin-6 (P £ 0.02), were generally similar between GADA-positive and -negative individuals. GADA positivity did not predict incident diabetes in multiply adjusted (HR =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes mellitus; Glutamic acid decarboxylase; Auto-immune diseases; Inflammation; Risk factors. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700007 |
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