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	Provedor de dados 47 (1) Autor Chen,Cuixia (1) Cui,Lingling (1) Shang,Xin (1) Zeng,Xianlu (1) Palavra-chave Gene transcription (1) Nuclear transcriptional factor (1) Signal transduction (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2010 (1) País Argentina (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última NFAT regulates CSF-1 gene transcription triggered by L-selectin crosslinking 47 Chen,Cuixia; Cui,Lingling; Shang,Xin; Zeng,Xianlu. L-selectin is a member of the selectin family that play an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells. Furthermore, L-selectin can function as a signal molecule. In our previous studies, we reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce CSF-1 gene transcription greatly in the activated Jurkat cells. Furthermore, we found that NFAT can be recruited to the nucleus after L-selectin ligation, and the nuclear NFAT interacts with the CSF-1... Tipo: Info:eu-repo/semantics/article Palavras-chave: Signal transduction; Gene transcription; Nuclear transcriptional factor. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200001 Registros recuperados: 1 Primeira ... 1 ... Última

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