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| COMIM,CLARISSA M.; MATHIA,GISIANE B.; HOEPERS,ANDREZA; TUON,LISIANE; KAPCZINSKI,FLÁVIO; DAL-PIZZOL,FELIPE; QUEVEDO,JOÃO; ROSA,MARIA I.. |
| We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines and oxidative parameters in serum and tried to correlate them with the age and functionality of patients with Progressive Muscle Dystrophies (PMD). The patients were separated into six groups (case and controls pared by age and gender), as follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (±17.9 years old) had a decrease of functionality, an increase in the IL-1β and TNF-α levels and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD patients (±25.8 years old) had a decrease of BDNF and IL-10 levels and superoxide dismutase activity and an increase of IL-1β... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Progressive Muscular Dystrophies; BNDF; Cytokines; Oxidative stress. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401809 |
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| GIOVANELLA,FRANCIANNE; FERREIRA,GABRIELA K.; PRÁ,SAMIRA D.T. DE; CARVALHO-SILVA,MILENA; GOMES,LARA M.; SCAINI,GISELLI; GONÇALVES,RENATA C.; MICHELS,MONIQUE; GALANT,LETÍCIA S.; LONGARETTI,LUIZA M.; DAJORI,ANA LUIZA; ANDRADE,VANESSA M.; DAL-PIZZOL,FELIPE; STRECK,EMILIO L.; SOUZA,RENAN P. DE. |
| Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Primaquine; Chloroquine; Oxidative damage; DNA damage; Antimalarial drugs. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
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