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	Provedor de dados J. Venom. Anim. Toxins (2) Autor DORCE,V. A. C. (2) LEBRUN,I. (2) CARVALHO,F. F. (1) MARUO,V. M. (1) NENCIONI,A. L. A. (1) SANDOVAL,M. R. L. (1) Mais... Palavra-chave Tityus serrulatus (2) EEG record (1) Electroshock (1) Hippocampus (1) Learning and memory (1) Neurodegeneration (1) Open-field (1) Passive avoidance (1) Scorpion fractions (1) Scorpion neurotoxin (1) Seizure (1) T-maze (1) TS-8F toxin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2002 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Convulsive effects of some isolated venom fractions of the Tityus serrulatus scorpion: behavioral, electroencephalographic, and neuropathological aspects J. Venom. Anim. Toxins CARVALHO,F. F.; NENCIONI,A. L. A.; LEBRUN,I.; DORCE,V. A. C.; SANDOVAL,M. R. L.. It has been previously shown that the crude venom of Tityus serrulatus can cause convulsions. This study was designed to investigate the neurotoxic effects of B, C, G, and K fractions isolated from this venom. Intravenous injection of these fractions in mice (0.6 - 6.0 mg/kg body weight) showed that the C fraction is a potent convulsant and G fraction decreased the threshold for tonic hand limb extension elicited by transauricular electroshock. Unilateral injection of B, C, and K fractions, but not G fraction, into the hippocampus of rats (0.6 - 6.0 µg) caused electroencephalographic alterations consisting of spikes and epileptic discharges that began in the hippocampus and evolved to the cortex. The following motor signs were observed: movements of facial... Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpion fractions; Electroshock; Seizure; Neurodegeneration; EEG record; Hippocampus; Tityus serrulatus. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200008 EFFECTS OF SCORPION Tityus serrulatus VENOM TOXIN TS-8F ON RAT LEARNING AND MEMORY J. Venom. Anim. Toxins MARUO,V. M.; LEBRUN,I.; DORCE,V. A. C.. Scorpion venom neurotoxins are responsible for toxicity and pharmacological effects. They are active in sodium and potassium channels leading to an increase in the release of neurotransmitters, such as glutamate. Glutamate is found in large quantities in the hippocampus (HPC) and is involved in the long-term potentiation (LTP) induction. The HPC is known to be related to certain kinds of memory. The aim of this study is to evaluate the effects of Tityus serrulatus TS-8F toxin on rat behavior with emphasis on learning and memory. We analyzed the effects of different doses of TS-8F on rat behavior in home cages, open-field (habituation), inhibitory avoidance, T-maze, and hippocampus morphology. In the first two experiments, 0.05µg/animal dose of TS-8F did... Tipo: Info:eu-repo/semantics/article Palavras-chave: Learning and memory; Scorpion neurotoxin; Tityus serrulatus; T-maze; Open-field; Passive avoidance; TS-8F toxin. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100007 Registros recuperados: 2 Primeira ... 1 ... Última

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