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	Provedor de dados BJMBR (2) Autor Bertho,A.L. (2) Coutinho,S.G. (2) Da-Cruz,A.M. (2) Santiago,M.A. (2) De-Luca,P. (1) Palavra-chave /font> (1) Apoptosis (1) Cell death (1) FONT FACE=Symbol> (1) Flow cytometry (1) G< (1) Human cutaneous leishmaniasis Leishmania braziliensis CD4+ and CD8+ cells IFN-< (1) Human leishmaniasis (1) IL-4 (1) T cells (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2000 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Immunologic patterns associated with cure in human American cutaneous leishmaniasis BJMBR Coutinho,S.G.; Da-Cruz,A.M.; Bertho,A.L.; Santiago,M.A.; De-Luca,P.. Patients with American cutaneous leishmaniasis were studied before therapy (active lesion) and at the end of therapy (cured patients). Assays of lymphocyte proliferative responses of peripheral blood mononuclear cells induced in vitro by Leishmania braziliensis promastigote antigens (Lb) were performed. Antigen-stimulated cells were harvested for CD4 and CD8 phenotype analysis and the levels of gamma interferon (IFN-<FONT FACE="Symbol">g</font>) and interleukin 4 (IL-4) produced were also determined in the culture supernatants. Two different patterns of Lb-induced T cell responses were observed: a) predominance of responding CD4+ cells and mixed type 1 and type 2 cytokine production (IFN-<FONT FACE="Symbol">g</font> and IL-4) during... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human cutaneous leishmaniasis Leishmania braziliensis CD4+ and CD8+ cells IFN-<; FONT FACE=Symbol>; G<; /font>; IL-4. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100019 Detection of early apoptosis and cell death in T CD4+ and CD8+ cells from lesions of patients with localized cutaneous leishmaniasis BJMBR Bertho,A.L.; Santiago,M.A.; Da-Cruz,A.M.; Coutinho,S.G.. Human localized cutaneous leishmaniasis (LCL), induced by Leishmania braziliensis, ranges from a clinically mild, self-healing disease with localized cutaneous lesions to severe forms which can present secondary metastatic lesions. The T cell-mediated immune response is extremely important to define the outcome of the disease; however, the underlying mechanisms involved are not fully understood. A flow cytometric analysis of incorporation of 7-amino actinomycin D and CD4+ or CD8+ T cell surface phenotyping was used to determine whether different frequencies of early apoptosis or accidental cell death occur at different stages of LCL lesions. When all cells obtained from a biopsy sample were analyzed, larger numbers of early apoptotic and dead cells were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Flow cytometry; Human leishmaniasis; Cell death; T cells. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300010 Registros recuperados: 2 Primeira ... 1 ... Última

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