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	Provedor de dados 56 (1) Autor Borissevitch,I.E. (1) Daghastanli,N.A. (1) Degterev,I.A. (1) Tedesco,A.C. (1) Palavra-chave Nitrofurane derivatives (1) Oxygen and nitrogen active species (1) Phototoxicity (1) Quinifuryl (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2004 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Photocytotoxicity of a 5-nitrofuran-ethenyl-quinoline antiseptic (Quinifuryl) to P388 mouse leukemia cells 56 Daghastanli,N.A.; Degterev,I.A.; Tedesco,A.C.; Borissevitch,I.E.. Quinifuryl (MW 449.52), 2-(5'-nitro-2'-furanyl)ethenyl-4-{N-[4'-(N,N-diethylamino)-1'-methylbutyl]carbamoyl} quinoline, is a water soluble representative of a family of 5-nitrofuran-ethenyl-quinoline drugs which has been shown to be highly toxic to various lines of transformed cells in the dark. In the present study, the toxicity of Quinifuryl to P388 mouse leukemia cells was compared in the dark and under illumination with visible light (390-500 nm). Illumination of water solutions of Quinifuryl (at concentrations ranging from 0.09 to 9.0 µg/ml) in the presence of P388 cells resulted in its photodecomposition and was accompanied by elevated cytotoxicity. A significant capacity to kill P388 cells was detected at a drug concentration as low as 0.09 µg/ml.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phototoxicity; Nitrofurane derivatives; Quinifuryl; Oxygen and nitrogen active species. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200013 Registros recuperados: 1 Primeira ... 1 ... Última

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