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| Olivoto,R.R.; Damiani,C.E.N.; Kassouf Silva,I.; Lofrano-Alves,M.S.; Oliveira,M.A.; Fogaça,R.T.H.. |
| In cardiac and skeletal muscle, eugenol (μM range) blocks excitation-contraction coupling. In skeletal muscle, however, larger doses of eugenol (mM range) induce calcium release from the sarcoplasmic reticulum. The effects of eugenol are therefore dependent on its concentration. In this study, we evaluated the effects of eugenol on the contractility of isolated, quiescent atrial trabeculae from male Wistar rats (250-300 g; n=131) and measured atrial ATP content. Eugenol (1, 3, 5, 7, and 10 mM) increased resting tension in a dose-dependent manner. Ryanodine [100 µM; a specific ryanodine receptor (RyR) blocker] and procaine (30 mM; a nonspecific RyR blocker) did not block the increased resting tension induced by eugenol regardless of whether extracellular... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eugenol; Atrial trabeculae; Resting tension; Ryanodine; Rat; ATP. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000400328 |
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| Soares,M.C.M.S.; Damiani,C.E.N.; Moreira,C.M.; Stefanon,I.; Vassallo,D.V.. |
| Eucalyptol is an essential oil that relaxes bronchial and vascular smooth muscle although its direct actions on isolated myocardium have not been reported. We investigated a putative negative inotropic effect of the oil on left ventricular papillary muscles from male Wistar rats weighing 250 to 300 g, as well as its effects on isometric force, rate of force development, time parameters, post-rest potentiation, positive inotropic interventions produced by Ca2+ and isoproterenol, and on tetanic tension. The effects of 0.3 mM eucalyptol on myosin ATPase activity were also investigated. Eucalyptol (0.003 to 0.3 mM) reduced isometric tension, the rate of force development and time parameters. The oil reduced the force developed by steady-state contractions (50%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eucalyptol; Myocardial contractility; Calcium; Isoproterenol; Tetanic tension. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300017 |
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