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	Provedor de dados BJMBR (3) Autor De-Oliveira,A.C.A.X. (3) Paumgartten,F.J.R. (3) Fidalgo-Neto,A.A. (2) Manhães-Rocha,D.A. (2) Conte,F.P. (1) Kuriyama,S.N. (1) Silva,I.B. (1) Mais... Palavra-chave Monooxygenases (2) Biotransformation (1) Bixaceae (1) Cytochrome P-450 (1) Cytochrome P450 (1) Food additive Natural color Cytochrome P450 Drug metabolizing enzymes Carotenoids (1) Gestation (1) Granuloma (1) Liver microsomes (1) Pharmacokinetics (1) Schistosoma mansoni (1) Undernutrition (1) Xenobiotic metabolism (1) Mais... Tipo do documento Info:eu-repo/semantics/other (3) Ano 2007 (1) 2003 (1) 2000 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Activity of liver microsomal enzymes during the chronic phase of murine schistosomiasis BJMBR Conte,F.P.; Fidalgo-Neto,A.A.; Manhães-Rocha,D.A.; Paumgartten,F.J.R.; De-Oliveira,A.C.A.X.. The effects of schistosomiasis on microsomal enzymes were studied on post-infection day 90 when accumulated damage and fibrosis are most intense but granulomatous reaction around the eggs harbored in the liver is smaller than during the earlier phases. Swiss Webster (SW) and DBA/2 mice of either sex (N = 12 per sex per group) were infected with 100 Schistosoma mansoni cercariae on postnatal day 10 and killed on post-infection day 90. Cytochrome P-450 (CYP) concentration and alkoxyresorufin-O-dealkylases (EROD, MROD, BROD, and PROD), p-nitrophenol-hydroxylase (PNPH), coumarin-7-hydroxylase (COH), and UDP-glucuronosyltransferase (UGT) activities were measured in hepatic microsomes. Age-matched mice of the same sex and strain were used as controls. In S.... Tipo: Info:eu-repo/semantics/other Palavras-chave: Schistosoma mansoni; Pharmacokinetics; Cytochrome P-450; Monooxygenases; Granuloma; Liver microsomes. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500008 Effects of pregnancy and protein-energy malnutrition on monooxygenase O-dealkylation activity in rat liver microsomes BJMBR Kuriyama,S.N.; De-Oliveira,A.C.A.X.; Fidalgo-Neto,A.A.; Paumgartten,F.J.R.. Xenobiotic metabolism is influenced by a variety of physiological and environmental factors including pregnancy and nutritional status of the individual. Pregnancy has generally been reported to cause a depression of hepatic monooxygenase activities. Low-protein diets and protein-energy malnutrition have also been associated with a reduced activity of monooxygenases in nonpregnant animals. We investigated the combined effects of pregnancy and protein-energy malnutrition on liver monooxygenase O-dealkylation activity. On pregnancy day 0 rats were assigned at random to a group fed ad libitum (well-nourished, WN) or to a malnourished group (MN) which received half of the WN food intake (12 g/day). WN and MN rats were killed on days 0 (nonpregnant), 11 or 20... Tipo: Info:eu-repo/semantics/other Palavras-chave: Cytochrome P450; Monooxygenases; Xenobiotic metabolism; Undernutrition; Gestation; Biotransformation. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100014 Induction of liver monooxygenases by annatto and bixin in female rats BJMBR De-Oliveira,A.C.A.X.; Silva,I.B.; Manhães-Rocha,D.A.; Paumgartten,F.J.R.. Annatto or urucum is an orange-yellow dye obtained from Bixa orellana seeds. It has been used as a natural dye in a variety of food products, drugs and cosmetics, and also in Brazilian cuisine as a condiment ('colorau'). Bixin, a carotenoid devoid of provitamin A activity, is the main pigment found in annatto. Some carotenoids (canthaxanthin, astaxanthin and ß-Apo-8'-carotenal) are known to be potent inducers of CYP1A1, a property not shared by others (ß-carotene, lycopene and lutein). Little is known, however, about the CYP1A1-inducing properties of bixin and annatto. The present study was performed to determine the effects of an annatto extract (28% bixin) and bixin (95% pure) on rat liver monooxygenases. Adult female Wistar rats were treated by gavage... Tipo: Info:eu-repo/semantics/other Palavras-chave: Food additive Natural color Cytochrome P450 Drug metabolizing enzymes Carotenoids; Bixaceae. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100015 Registros recuperados: 3 Primeira ... 1 ... Última

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