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| Devia,Cristina M.; Pappano,Nora B.; Debattista,Nora B.. |
| The bacteriostatic activity of 2,4,2-trihydroxychalcone; 2,4,3-trihydroxychalcone and 2,4,4-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against Staphylococcus aureus ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against S. aureus were determined by the broth dilution method and the results obtained were compared to that of 2',4'-dihydroxychalcone. The sequence observed was: MIC 2,4,3-(OH)3 > MIC 2,4-(OH)2 > MIC 2,4,4-(OH)3 > > MIC 2,4,2-(OH)3. These results showed that the introduction of an electron... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bacteriostatic activity; Structure-activity relationship; Flavonoids; Trihydroxylated chalcones. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141998000400014 |
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| Alvarez,María De Los Angeles; Zarelli,Valeria E. P.; Pappano,Nora B.; Debattista,Nora B.. |
| In previous work the bacteriostatic action of trihydroxylated chalcones against Staphylococcus aureus ATCC 25 923 was investigated. In this work the action of 2´,4´,2-(OH)3-chalcone, 2´,4´,3-(OH)3- chalcone and 2´,4´,4-(OH)3 -chalcone against Escherichia coli ATCC 25 922 was evaluated. Growth kinetic curves of E.coli were made in nutritive broth added with increasing drug concentrations. The specific growth rates of the microorganisms were calculated by a kinetic turbidimetric method, which was previously probed and the minimal inhibitory concentrations (MIC´s) were evaluated by a mechanism of action proposed. The MICs of 2´,4´,3-(OH)3-chalcone and 2´,4´,2-(OH)3-chalcone were 46 mg/ml and 122 mg/ml, respectively. The 2´,4´,4-(OH)3-chalcone was inactive.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chalcones; Bacteriostatic Activity; Hydroxylation. |
| Ano: 2004 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452004000100004 |
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| Olivella,Mónica S.; Debattista,Nora B.; Pappano,Nora B.. |
| Considering the skin´s function, different dermal pharmaceutical forms can be developed according to the type of therapeutic activity, active principle and excipients involved in the formulation, such as transdermal preparations. In the present study, the permeation parameters of the non-steroidal antiinflammatory drug, salicylic acid (SA) through synthetic membrane, polyvinyliden difluoride, and a biological membrane, egg shell membrane, with different vehicles, propylene glycol, isopropyl alcohol and carbopol gel, were determined. The reported physicochemical parameters of SA from CG were significantly higher than those obtained using PG and IP. This is attributed to the lipophilic nature of the vehicle that facilitates the release and penetration of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Membranes; Permeation; Drug release; Salicylic acid. |
| Ano: 2006 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000200008 |
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| Olivella,Mónica S.; Zarelli,Valeria E.P.; Pappano,Nora B.; Debattista,Nora B.. |
| Among other properties, flavonoids present a notable bacteriostatic activity. In this paper, minimal inhibitory concentrations (MICs) of 5,7,4'-trihydroxyflavanone (naringenin), 5,7-dihydroxyflavone and 2',4',4- trihydroxychalcone (isoliquitirigenin) against Staphylococcus aureus ATCC 25 923 were determined and compared to values obtained for other chalcones and flavanones previously investigated. Specific growth rates and MICs were determined by a turbidimetric kinetic method. The observed sequence MICflavanone (inactive) >MIC7-hidroxyflavanone (197.6 µgml-1)>MIC5,7,4'-trihydroxyflavanone (120 µgml-1) showed that the introduction of an electron donating group (-OH) causes an increase in bioactivity. On the other hand, the comparisons... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Flavanone; Flavone; Chalcone; Bacteriostatic activity. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000300013 |
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