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| Mendes,Thiago Marques; Oliveira,Léa Campos de; Yamamoto,Lídia; Del Negro,Gilda Maria Barbaro; Okay,Thelma Suely. |
| Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis, plays a significant role as a cofactor in the process of tumorigenesis, and has consistently been associated with a variety of malignancies especially in immunocompromised patients. Forty-four children and adolescents (21 liver transplant patients, 7 heart transplant, 5 AIDS, 3 autoimmune hepatitis, 2 nephritic syndromes, 2 medullar aplasia, 2 primary immunodeficiency disorder patients, 1 thrombocytopenic purpura and 1 systemic lupus erythematosus) presenting with chronic active EBV infection (VCA-IgM persistently positive; VCA-IgG > 20 AU/mL and positive IgG _ EBNA) had peripheral blood samples obtained during clinically characterized EBV reactivation episodes. DNA samples were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: EBVA; EBNA-2; Infectious mononucleosis; Lymphoproliferative disorder; EBV genotyping; EBV-PCR. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300005 |
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| Cezarino,Bruno Nicolino; Yamamoto,Lidia; Del Negro,Gilda Maria Barbaro; Rocha,Daisy; Okay,Thelma Suely. |
| Group B streptococcus (GBS) remains the most common cause of early-onset sepsis in newborns. Laboratory gold-standard, broth culture methods are highly specific, but lack sensitivity. The aim of this study was to validate a nested-PCR and to determine whether residue volumes of urine samples obtained by non invasive, non sterile methods could be used to confirm neonatal GBS sepsis. The nested-PCR was performed with primers of the major GBS surface antigen. Unavailability of biological samples to perform life supporting exams, as well as others to elucidate the etiology of infections is a frequent problem concerning newborn patients. Nevertheless, we decided to include cases according to strict criteria: newborns had to present with signs and symptoms... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: GBS; Neonatal sepsis; Early-onset neonatal sepsis; Neonatal infection; PCR; Nested-PCR. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000100005 |
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