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	Provedor de dados BJID (2) Autor Deng,Shaoli (2) Chen,Ming (1) Li,Yanlin (1) Luo,Jie (1) Yan,Baosong (1) Zeng,Zhaofang (1) Zhang,Kejun (1) Zhang,Mingxu (1) Mais... Palavra-chave Active tuberculosis (1) IL-10 (1) IL-17 (1) Macrophage migration inhibitory factors (1) Microsatellite polymorphism (1) Susceptibility (1) Th17 (1) Treg (1) Tuberculosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2017 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Imbalance of Th17 and Treg in peripheral blood mononuclear cells of active tuberculosis patients BJID Luo,Jie; Zhang,Mingxu; Yan,Baosong; Zhang,Kejun; Chen,Ming; Deng,Shaoli. Abstract Objective: Maintaining a right balance between Th17 and Treg might be critical to the immunopathogenesis of active tuberculosis (TB). This study aimed to assess whether the Th17/Treg balance is altered in active TB patients. Methods: 250 study subjects (90 active TB patients, 80 latent TB subjects, and 80 healthy controls) were recruited for the study. The expression of Th17 and Treg in peripheral blood mononuclear cells (PBMCs) in the 250 subjects was investigated by flow cytometry. Plasma levels of cytokines IL-17 and IL-10, which are related to Th17 and Treg, respectively, were determined by ELISA. Results: The percentages of Th17 and Treg in PBMCs from active TB patients were significantly higher than those from latent TB or control groups... Tipo: Info:eu-repo/semantics/article Palavras-chave: Active tuberculosis; Th17; Treg; IL-17; IL-10. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200155 Study of the relationship between human MIF level, MIF-794CATT5-8 microsatellite polymorphism, and susceptibility of tuberculosis in southwest China BJID Li,Yanlin; Zeng,Zhaofang; Deng,Shaoli. OBJECTIVE: To study the human migration inhibitory factor (MIF) level in tuberculosis (TB) patients, and the relationship between MIF-794CATT microsatellite polymorphism and susceptibility of TB in Southwest China. METHODS: TB patients (n = 151) and healthy unrelated controls (n = 149) were recruited for this study. Genomic DNA was extracted, and then amplified by polymerase chain reaction (PCR). MIF-794CATT5-8 microsatellite polymorphism was genotyped by DNA sequencing. MIF level was detected by ELISA. RESULTS: In the TB group, the repeat number of 7/7 and 7/8 (17.89%) was significantly higher than that of the control group (8.05%), and the serum MIF level was also much higher than that of the healthy controls (705.21 ± 67.98 vs. 355.31 ± 57.29 pg/mL, p... Tipo: Info:eu-repo/semantics/other Palavras-chave: Macrophage migration inhibitory factors; Tuberculosis; Microsatellite polymorphism; Susceptibility. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400013 Registros recuperados: 2 Primeira ... 1 ... Última

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