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	Provedor de dados BJPS (2) Autor Dezani,André Bersani (2) Serra,Cristina Helena dos Reis (2) Caffaro,Arthur Massabki (1) Dezani,Thaisa Marinho (1) Ferreira,Julie Caroline Ferrari (1) Pereira,Thaisa Marinho (1) Reis,Juliana Mazza (1) Mais... Palavra-chave Biopharmaceutical Classification System (1) Biopharmaceutics Classification System (BCS) (1) Biopharmaceutics Drug Disposition Classification System (BDDCS) (1) Didanosine/solubility (1) Drugs/dissolution rate (1) Drugs/solubility (1) Equilibrium solubility (1) Intrinsic dissolution (1) Intrinsic dissolution/biopharmaceutical classification (1) Intrinsic dissolution/method (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Solubility evaluation of didanosine: a comparison between the equilibrium method and intrinsic dissolution for biopharmaceutics classification purposes BJPS Dezani,André Bersani; Dezani,Thaisa Marinho; Ferreira,Julie Caroline Ferrari; Serra,Cristina Helena dos Reis. ABSTRACT BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) were proposed as tools for classifying drugs into four categories. Both systems consider the solubility as an important characteristic for the classification of compounds in drug development and in vivo disposition prediction. Although some results of drug solubility can be found in the literature, the aforementioned characteristic is not entirely clear when considering didanosine (ddI). Based on that, the solubility of ddI was evaluated using equilibrium and intrinsic dissolution methods. For the equilibrium method, excess amount of ddI was added to each media until obtaining a supersaturated solution and the mixture was submitted to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Didanosine/solubility; Biopharmaceutics Classification System (BCS); Biopharmaceutics Drug Disposition Classification System (BDDCS); Intrinsic dissolution; Equilibrium solubility. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200632 Equilibrium solubility versus intrinsic dissolution: characterization of lamivudine, stavudine and zidovudine for BCS classification BJPS Dezani,André Bersani; Pereira,Thaisa Marinho; Caffaro,Arthur Massabki; Reis,Juliana Mazza; Serra,Cristina Helena dos Reis. Solubility and dissolution rate of drugs are of major importance in pre-formulation studies of pharmaceutical dosage forms. The solubility improvement allows the drugs to be potential biowaiver candidates and may be a good way to develop more dose-efficient formulations. Solubility behaviour of lamivudine, stavudine and zidovudine in individual solvents (under pH range of 1.2 to 7.5) was studied by equilibrium solubility and intrinsic dissolution methods. In solubility study by equilibrium method (shake-flask technique), known amounts of drug were added in each media until to reach saturation and the mixture was subjected to agitation of 150 rpm for 72 hours at 37 ºC. In intrinsic dissolution test, known amount of each drug was compressed in the matrix of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Drugs/solubility; Drugs/dissolution rate; Intrinsic dissolution/method; Intrinsic dissolution/biopharmaceutical classification; Biopharmaceutical Classification System. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400026 Registros recuperados: 2 Primeira ... 1 ... Última

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