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Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses BJMBR
Diniz,L.; dos Reis,B.B.; de Castro,G.M.; Medalha,C.C.; Viana,M.B..
It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Corticosterone; Imipramine; Generalized anxiety disorder; Panic disorder; Elevated T-maze.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000010
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