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	Provedor de dados Nature Precedings (1) Autor Djordje Bajic (1) Juan F. Poyatos (1) Palavra-chave Bioinformatics (1) Evolutionary Biology (1) Genetics & Genomics (1) Molecular Cell Biology (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Balancing noise and plasticity in gene expression Nature Precedings Djordje Bajic; Juan F. Poyatos. Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling? Transcription re-initiation is generally associated with coupling and this is commonly related to strong chromatin regulation. We alternatively show how strong regulation can however lead to plasticity uncorrelated to noise. The character of the regulation is also relevant, with plastic but noiseless genes usually subjected to broad expression activation whereas plastic and noisy genes experience targeted repression. This differential action is similarly noticed in how histones influence these genes. In contrast, we find that translational... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Molecular Cell Biology; Bioinformatics; Evolutionary Biology. Ano: 2011 URL: http://precedings.nature.com/documents/6729/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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