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| Dorian Aur. |
| It is generally believed that spike timing features (firing rate, ISI) are the main characteristics that can be related to neural code. Contrary to this common belief, spike directivity, a new measure that quantifies transient charge density dynamics within action potentials (APs) provides better results in discriminating different categories of visual object recognition. Specifically, intracranial recordings from medial temporal lobe (MTL) of epileptic patients have been analyzed using firing rate, interspike intervals and spike directivity. A comparative statistical analysis of the same spikes from four selected neurons shows that electrical micro-mapped features in neurons display higher separability to input images compared to spike timing features. If... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5345/version/2 |
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| Dorian Aur. |
| The occurrence of seizures is a rare event with a very low probability of incidence. Therefore, a new paradigm is required to understand how epileptic seizures are generated. Specifically, analytical models and experimental data analysis show that the process underlying seizure generation is a severe dysfunctional regulation of neuronal activity inside the epileptogenic region. Translated into significant changes of endogenous electric field, this dysfunction acts at fundamental level of charge dynamics and leads to chaotic diffusion and electrical resonances within clustered regions with high frequency oscillations (HFO). Since the altered regulation can be modeled by perturbed Hamiltonian systems with many degrees of freedom that describe the motion of... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5398/version/1 |
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| Dorian Aur; Mandar S. Jog. |
| This paper highlights ionic fluxes as information carriers in neurons. The theoretical framework regarding information transfer is presented as changes in the thermodynamic entropy that underlie specific computations determined by ionic flow. The removal or accumulation of information is analyzed in terms of ionic mass transfer related with changes in Shannon information entropy. Specifically, information transfer occurs during an action potential (AP) via the voltage gated ion channels in membranes and the same physical mechanism can be extended to various types of synapses. Since sequential APs from a selected neuron are not alike, then every spike may transfer slightly different amounts of information during their occurrence. The average efficiency in... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1254/version/1 |
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| Dorian Aur; Mandar Jog. |
| The present study reveals the existence of an intrinsic spatial code within neuronal spikes that predicts behavior. As rats learnt a T-maze procedural task, simultaneous changes in temporal occurrence of spikes and spike directivity are evidenced in “expert” neurons. While the number of spikes between the tone delivery and the beginning of turn phase reduced with learning, the generated spikes between these two events acquired behavioral meaning that is of highest value for action selection. Spike directivity is thus a hidden feature that reveals the semantics of each spike and in the current experiment, predicts the correct turn that the animal would subsequently make to obtain reward. Semantic representation of behavior can then be... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/61/version/1 |
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| Dorian Aur; Peter N. Steinmetz. |
| It is generally believed that spike timing features (firing rate, ISI) are the main characteristics that can be related to neural code. Contrary to this common belief, spike directivity, a new measure that quantifies transient charge density dynamics within action potentials (APs) provides better results in discriminating different categories of visual object recognition. Specifically, intracranial recordings from medial temporal lobe (MTL) of epileptic patients have been analyzed using firing rate, interspike intervals and spike directivity. A comparative statistical analysis of the same spikes from four selected neurons shows that electrical micro-mapped features in neurons display higher separability to input images compared to spike timing features. If... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5345/version/1 |
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