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| Castro,L.; Varjão,B.; Silva,I.; Duque,B.; Batista,A.; Santana,R.; Luz,P.; Rocha Junior,M.A.; Fregoneze,J.B.; De Castro-e-Silva,E.. |
| We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 ± 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 ± 0.41 ml, N = 12; salt load + saline = 5.74 ± 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: 5-HT4 receptors; Water intake; Hyperosmolarity; Hypovolemia. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600015 |
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