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Novel Pharmaceuticals from Kenyan Marine Cyanobacteria OceanDocs
Dzeha, T..
Two projects undertaken at the Heriot-Watt University, Edinburgh, U.K as part of the WIOMSA Marg II Programme are presented here. Project 1 was on studies carried out on the Kenyan marine cyanobacterium Lyngbya majuscula, which was collected from Shimoni, 100 km south of Mombasa, Kenya and ferried to the U.K on 12th October 2003. Specifically, L. majuscula was investigated on the potential for bioprocess intensified production of secondary metabolites with therapeutic potential, the Chemistry of its secondary metabolites and that of the cultures, and on the 16S rDNA classification of its epiphytic bacteria isolates. Project 2 focused on the isolation of cell-cell signaling inducer compounds from biofilms of marine bacteria Bacillus licheniformis EI-34-6.
Tipo: Report Palavras-chave: Pharmaceuticals; Aquatic plants; Medical plants Bacteria Pharmaceutical products Bacteria Pharmaceutical plants http://aims.fao.org/aos/agrovoc/c_765 http://aims.fao.org/aos/agrovoc/c_13278.
Ano: 2004 URL: http://hdl.handle.net/1834/1291
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Clionasterol, a Triterpenoid from the Kenyan Marine Green Macroalga Halimeda macroloba OceanDocs
Jaspars, M.; Dzeha, T.; Tabudravu, J..
The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.
Tipo: Journal Contribution Palavras-chave: Algae.
Ano: 2003 URL: http://hdl.handle.net/1834/963
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