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Evolutionary history and genetic parallelism affect correlated responses to evolution ArchiMer
Le Gac, Mickael; Cooper, Tim F.; Cruveiller, Stephane; Edigue, Claudine M.; Schneider, Dominique.
We investigated the relationship between genomic and phenotypic evolution among replicate populations of Escherichia coli evolved for 1000 generations in four different environments. By resequencing evolved genomes, we identified parallel changes in genes encoding transcription regulators within and between environments. Depending on both the environment and the altered gene, genetic parallelism at the gene level involved mutations that affected identical codons, protein domains or were widely distributed across the gene. Evolved clones were characterized by parallel phenotypic changes in their respective evolution environments but also in the three alternative environments. Phenotypic parallelism was high for clones that evolved in the same environment,...
Tipo: Text Palavras-chave: Adaptation; Epistasis; Experimental evolution; Genome sequencing; Parallelism.
Ano: 2013 URL: https://archimer.ifremer.fr/doc/00148/25928/24096.pdf
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