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	Provedor de dados BJMBR (2) Autor Borojevic,R. (2) El-Cheikh,M.C. (2) Aguiar,A.M. (1) Gomes,L. (1) Oliveira,F.L. (1) Pereira,D.A. (1) Mais... Palavra-chave B lymphocytes (1) Ectoenzyme (1) Exopeptidase (1) Hematopoiesis (1) Immunoglobulin switch (1) Membrane rafts (1) Schistosomiasis (1) Stroma (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Dipeptidyl peptidase IV (CD26) activity in the hematopoietic system: differences between the membrane-anchored and the released enzyme activity BJMBR Pereira,D.A.; Gomes,L.; El-Cheikh,M.C.; Borojevic,R.. Dipeptidyl peptidase IV (DPP-IV; CD26) (EC 3.4.14.5) is a membrane-anchored ectoenzyme with N-terminal exopeptidase activity that preferentially cleaves X-Pro-dipeptides. It can also be spontaneously released to act in the extracellular environment or associated with the extracellular matrix. Many hematopoietic cytokines and chemokines contain DPP-IV-susceptible N-terminal sequences. We monitored DPP-IV expression and activity in murine bone marrow and liver stroma cells which sustain hematopoiesis, myeloid precursors, skin fibroblasts, and myoblasts. RT-PCR analysis showed that all these cells produced mRNA for DPP-IV. Partially purified protein reacted with a commercial antibody to CD26. The K M values for Gly-Pro-p-nitroanilide ranged from 0.43 to 0.98... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hematopoiesis; Stroma; Exopeptidase; Ectoenzyme; Membrane rafts. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500003 IgE expression on the surface of B1 and B2 lymphocytes in experimental murine schistosomiasis BJMBR Oliveira,F.L.; Aguiar,A.M.; Borojevic,R.; El-Cheikh,M.C.. In a previous study we monitored the distribution and phenotype expression of B1 cells during the evolution of experimental murine schistosomiasis mansoni and we proposed that the B1 cells were heterogeneous: a fraction which originated in the spleen and followed the migratory pathway to mesenteric ganglia, while the other was the resident peritoneal B1-cell pool. In the present study, we have addressed the question of whether these two B1-lymphocyte populations are involved in the production of the late Ig isotype IgE, which is present in high levels in schistosomal infection. Lymphocyte expression of surface markers and immunoglobulins were monitored by immunofluorescence flow cytometry. Both in the spleen and mesenteric ganglia, the B1 and B2 cells were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Schistosomiasis; B lymphocytes; Immunoglobulin switch. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700006 Registros recuperados: 2 Primeira ... 1 ... Última

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