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| Ribeiro,Mara Fernandes; Oliveira,Felipe Leite de; Souza,Aline Moreira; Machado,Thelma de Barros; Cardoso,Priscilla Farinhas; Patti Sobrinho,Andrea; Nascimento,Angélica Silveira; Souza,Cláudio Maurício Vieira de; Elias,Sabrina Calil. |
| ABSTRACT Background: Accidents caused by spiders of the genus Loxosceles constitute an important public health problem in Brazil. The venom of Loxosceles sp induces dermonecrosis at the bite site and systemic disease in severe cases. Traditional medicine based on plant-derived products has been proven to reduce the local effects of envenomation. The present study verified the healing effects of copaiba oil on lesions induced by the venom of L. intermedia. Methods: Cutaneous lesions were induced on the backs of rabbits by intradermal injection of L. intermedia venom. Copaiba oil was applied topically 6 hours after injection; the treatment was repeated for 30 days, after which animal skins were removed and processed for histopathological analysis. Blood... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Loxosceles intermedia; Venom; Skin lesion; Copaiba oil; Topical treatment. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100310 |
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