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| Wahle,Raul Carlos; Perez,Renata Mello; Pereira,Patrícia Fucuta; Oliveira,Elze Maria Gomes; Emori,Christini Takemi; Uehara,Silvia Naomi de Oliveira; Silva,Ivonete Sandra de Souza; Silva,Antônio Eduardo Benedito; Ferraz,Maria Lucia Gomes. |
| ABSTRACTIn coinfected HBV/HCV patients, HBV replication is usually suppressed by HCV over the time. No study to date has evaluated the HBV viremia in long-term follow-up after HCV treatment in hemodialysis patients with HBV/HCV coinfection. This study aimed to assess the evolution of HBV viremia after HCV treatment in this special population. Ten hemodialysis patients with HBV/HCV coinfection with dominant HCV infection (HBV lower than 2000 IU/mL) and significant fibrosis were treated with interferon-alpha 3 MU 3×/week for 12 months and could be followed for at least 36 months after HCV treatment. Six cases of HBV reactivation (60%) during follow-up were observed and 5/6 had been successfully treated for HCV. Patients with HBV reactivation received... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Coinfection HBV/HCV; Reactivation HBV; Hemodialysis. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500533 |
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| Emori,Christini Takemi; Perez,Renata Melo; Matos,Carla Adriana Loureiro de; Uehara,Silvia Naomi Oliveira; Pereira,Patricia da Silva Fucuta; Feldner,Ana Cristina Amaral; Carvalho Filho,Roberto José de; Silva,Ivonete Sandra de Souza e; Silva,Antonio Eduardo Benedito; Ferraz,Maria Lucia Gomes. |
| Introduction:There is scarce information regarding clinical evolution of HBV infection in renal transplant patients.Aims:To evaluate the prevalence of acute exacerbation in HBV-infected renal transplant patients and its association with the time after transplantation, presence of viral replication, clinical evolution, and use of antiviral prophylaxis.Materials and methods:HBV infected renal transplant patients who underwent regular follow-up visits at 6-month intervals were included in the study. The criteria adopted to characterize exacerbation were: ALT >5 × ULN and/or >3 × baseline level. Predictive factors of exacerbation evaluated were age, gender, time on dialysis, type of donor, post-transplant time, ALT, HBeAg, HBV-DNA, HCV-RNA,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Renal transplantation; Hepatitis B; ALT flare; Lamivudine. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600625 |
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| de Oliveira Uehara,Silvia Naomi; Emori,Christini Takemi; Perez,Renata Mello; Mendes-Correa,Maria Cassia Jacintho; de Souza Paiva Ferreira,Adalgisa; de Castro Amaral Feldner,Ana Cristina; Silva,Antonio Eduardo Benedito; Filho,Roberto José Carvalho; de Souza e Silva,Ivonete Sandra; Ferraz,Maria Lucia Cardoso Gomes. |
| Abstract Brazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed tuberculosis cases that occurred during α-interferon-based therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen tuberculosis cases were observed in patients submitted to hepatitis C α-interferon-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary tuberculosis; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to tuberculosis reactivation and... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hepatitis C; Tuberculosis; Alpha-interferon; Latent tuberculosis infection. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200205 |
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