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| Güllü,Gökçe; Peker,Irem; Haholu,Aptullah; Eren,Fatih; Küçükodaci,Zafer; Güleç,Bülent; Baloglu,Hüseyin; Erzik,Can; Özer,Ayse; Akkiprik,Mustafa. |
| The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015). Samples with no immunohistochemical staining for IGFBP5 showed increased... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Breast cancer; ER alpha; IGFBP5; Micro RNA; MiR-140; MiR-193b. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100021 |
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