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Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections Electron. J. Biotechnol.
Vilos,Cristian; Constandil,Luis; Herrera,Natalia; Solar,Paula; Escobar-Fica,Jorge; Velásquez,Luis Alberto.
Background: The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. The formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. Accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. Results: In this work, we formulated ceftiofur-loaded PHBV microparticles (PHBV-CEF) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. The...
Tipo: Journal article Palavras-chave: Ceftiofur; Drug delivery; Livestock breeding industry; PHBV; Polymeric microparticles.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582012000400001
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