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An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy Anais da ABC (AABC)
MESQUITA,MARIANA Q.; DIAS,CRISTINA J.; GAMELAS,SARA; FARDILHA,MARGARIDA; NEVES,MARIA G.P.M.S.; FAUSTINO,MARIA AMPARO F..
ABSTRACT Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Photodynamic therapy; Drug delivery; Liposomes; Silica nanoparticles; Gold nanoparticles; Polymeric micelles.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301101
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Evaluation of meso-substituted cationic corroles as potential antibacterial agents Anais da ABC (AABC)
CARDOTE,TERESA A.F.; BARATA,JOANA F.B.; AMADOR,CAROLINA; ALVES,ELIANA; NEVES,MARIA GRAÇA P.M.S.; CAVALEIRO,JOSÉ A.S.; CUNHA,ÂNGELA; ALMEIDA,ADELAIDE; FAUSTINO,MARIA AMPARO F..
ABSTRACT Cationic derivatives of 5,10,15-tris[4-(pyridin-4-ylsulphanyl)-2,3,5,6-tetrafluorophenyl]-corrolategallium(III)pyridine and 5,10,15-tris[4-(pyridin-2-ylsulfanyl)-2,3,5,6-tetrafluorophenyl]-correlategallium(III)pyridine were synthesized and their photosensitizing properties against the naturally bioluminescent Gram-negative bacterium Allivibrio fischeri were evaluated. The cationic corrole derivatives exhibited antibacterial activity at micromolar concentrations against this Gram-negative bacterium strain.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Allivibrio fischeri; Corroles; Photosensitizer; PDI; Bioluminescence.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301175
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