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| COMANDOLLI-WYREPKOWSKI,Claudia Dantas; JENSEN,Bruno Bezerra; GRAFOVA,Iryna; SANTOS,Pierre Alexandre dos; BARROS,Angela Maria Comapa; SOARES,Fabiane Veloso; BARCELLOS,José Fernando Marques; SILVA,Aline Fagundes da; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite. In the present study, the aim was to evaluate: i) phytochemical properties of extracts from Libidibia ferrea; ii) antileishmanial activity of extracts from L. ferrea against promastigotes and amastigotes of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) guyanensis; iii) the effects of topical treatment using hydrogel containing active extract of L. ferrea on golden hamsters infected with L. (L.) amazonensis. Extracts from leaves, branches and fruits of L. ferrea were obtained with hexane and methanol and were tested by in vitro assays in promastigotes and murine macrophages J774... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cutaneous leishmaniasis; Natural products; Topical formulations; Experimental treatment. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000400331 |
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| COMANDOLLI-WYREPKOWSKI,Claudia Dantas; GRAFOVA,Iryna; NAIFF,Maricleide de Farias; AVELLA,Maurizio; GENTILE,Gennaro; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Topical formulations; Experimental treatment; Pentamidine isethionate; Animal model; Leishmania. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000100039 |
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| FIGUEIRA,Luanda de Paula; SOARES,Fabiane Veloso; JÚNIOR,Roberto Daibes NAIFF; VINHOTE-SILVA,Alana Cristina; SILVA,Susi Simas da; ESPIR,Thaís Tibery; NAIFF,Maricleide de Farias; GOMES,Luis Henrique Monteiro; MOREIRA,Flávia Regina Almeida Campos Naief; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Few cases of human cutaneous leishmaniasis (CL) caused by Leishmania naiffi were described in the medical literature. The aim of this study was to report and analyze new cases of L. naiffi in the period between the years 1992 to 2011. The strains were characterized by isoenzyme analysis. All patients assisted had small lesions; ranging from 1.0x1.0 mm and 13.5x11.5 mm. The lesions observed were widely distributed: 55.5% on the lower limb, 5.5% in the abdominal area, 16.6% on upper limb and 22.2% in upper limb and back. Seventy-two percent of patients had ulcerated lesions. Clinical course of the disease varied from 1 to 10 months. According to gender, most infected individuals were men (83.3%). The patients came from Amazonas (10), Pará (01) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: American Tegumentary Leishmaniasis; Leishmania naiffi; Characterization; Experimental stations; Lutzomyia. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000100047 |
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