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| Registros recuperados: 27 | |
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| 山川, 和宏; 杉崎, 義一; 吉林台; 古林, 与志安; 古岡, 秀文; 佐々木, 直樹; 石井, 三都夫; 猪熊, 壽; YAMAKAWA, Kazuhiro; SUGISAKI, Giichi; Jilintai; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; SASAKI, Naoki; ISHII, Mitsuo; INOKUMA, Hisashi. |
| 2歳5カ月齢ホルスタイン雌乳牛が胸垂冷性浮腫，頸静脈拍動を呈し，心音聴取困難および心電図各波低電位所見から拡張型心筋症が疑われた．右胸腔には赤色変性性漏出液が多量に貯留しており，また超音波検査により心嚢水貯留を認めた．病理解剖の結果，心嚢は直径60cm大に腫大して血様心嚢水の貯留を認めたが，炎症あるいは腫瘍は認められず，血様心嚢水貯留の原因については不明であった．ただし右肩部に壊死巣を認めたことから，転倒等胸腔に強い衝撃を受けた可能性があると考えられた．心嚢水貯留が認められる場合には，心嚢腔内への出血も考慮すべき疾病のひとつであることが考えられた． A Holstein cow (two years and five months old) with jugular vein distension and non-inflammatory edema in the brisket showed decreased heart sound and abnormal waves on an electrocardiogram. Dilated cardiomyopathy was suspected. Unilateral pleural effusion was recovered from the right pleural cavity and found to be degenerated transudations. An ultrasonic cardiogram detected pericardial fluid. A pathological examination revealed that the pericardial cavity was enlarged with a... |
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Palavras-chave: 牛; 血様心嚢水; 片側性胸水貯留; Cow; Blood-like pericardium; Unilateral pleural efftusion. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2804 |
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| TAWFEEQ, Mohammad Monir; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; 猪熊, 壽. |
| Expression of six selective genes in peripheral blood cells was evaluated as diagnostic biomarkers for enzootic bovine leukosis (EBL) by using 10 EBL and 15 clinically healthy cattle. The clinically healthy cattle generally showed lower gene expression levels. Although wide variations of gene expression were found in some clinical cases of EBL, 4 and 5 among 10 EBL cattle showed higher expression of interleukin 2 receptor gene (IL2R) and Wilms’ tumor gene (WT1), respectively. Expression of IL2R in peripheral blood cells in EBL cattle was statistically increased; however, the lower sensitivity and higher variation in the gene expressions among clinical cases of EBL would be problems as diagnostic biomarkers. |
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Palavras-chave: Biomarkers; Enzootic bovine leukosis; Gene expression; QRT-PCR. |
| Ano: 2013 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3868 |
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| SASAKI, Naoki; MINAMI, Takuto; YAMADA, Kazutaka; SATOH, Motoyoshi; INOKUMA, Hisashi; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; YAMADA, Haruo; 佐々木, 直樹; 山田, 一孝; 猪熊, 壽; 古林, 与志安; 古岡, 秀文. |
| A 17-year-old, gray Thoroughbred gelding was presented with recurrent epistaxis following exercise for over one year. Multidetector-row computed tomographic (MDCT) examination of the head performed under general anesthesia indicated the presence of malignant melanoma. MDCT examination revealed the exact location and size of masses in the right guttural pouch first identified by endoscopy and in the left guttural pouch unidentified by endoscopy. MDCT examination revealed the presence of a blood clot that filled the right maxillary sinus. The horse was euthanized due to poor prognosis as a riding horse and the owner's decision, and MDCT findings were confirmed by postmortem examination. MDCT is suggested as a useful technique for diagnosis of head problems... |
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Palavras-chave: Equine; Malignant melanoma; MDCT. |
| Ano: 2007 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3104 |
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| CHIBA, Shiori; FUNATO, Shingo; HORIUCHI, Noriyuki; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu; 堀内, 雅之; 松本, 高太郎; 猪熊, 壽; 古岡, 秀文; 古林, 与志安. |
| Degeneration of the optic pathway has been reported in various animal species including cattle. We experienced a case of bilateral optic tract degeneration characterized by severe gliosis in a Japanese black cattle without any obvious visual defects. To evaluate the significance, pathological nature and pathogenesis of the lesions, we examined the optic pathway in 60 cattle (41 Japanese black, 13 Holstein and 6 crossbreed) with or without ocular abnormalities. None of these animals had optic canal stenosis. Degenerative changes with severe gliosis in the optic pathway, which includes the optic nerve, optic chiasm and optic tract, were only observed in 8 Japanese black cattle with or without ocular abnormalities. Furthermore, strong immunoreactivity of... |
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Palavras-chave: Axonal degeneration; Gliosis; Japanese black cattle; Optic pathway degeneration. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4123 |
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| 田川, 道人; 下田, 崇; 富樫, 義彦; 渡辺, 由紀; 古林, 与志安; 古岡, 秀文; 石井, 三都夫; 猪熊, 壽; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; ISHII, Mitsuo; INOKUMA, Hisashi. |
| 体表リンパ節の腫脹, 末梢血中における異型リンパ球出現を伴うリンパ球数の著増などの典型的な牛白血病症状を示していなかったことから, それぞれアミロイドーシス, 胸膜炎, 心疾患が疑われた3頭のホルスタイン種乳雌牛を病理解剖したところ, いずれも牛白血病と診断された. 血液検査および身体検査において著変が観察されない場合でも, 難診断時には鑑別診断リストに牛白血病を加えるべきであると考えられた. |
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Palavras-chave: 非典型的牛白血病; 鑑別診断. |
| Ano: 2008 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4005 |
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| YAMADA, Manabu; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; MATSUI, Takane; 古林, 与志安; 古岡, 秀文. |
| Autumn crocus poisoning of cattle is characterized by severe diarrhea caused by alkaloid colchicine. Previously, we examined pathologically this poisoning in cattle and reported that enterotoxic lesions were closely associated with apoptosis. To examine enterotoxicity of autumn crocus more precisely, a reproductive study was performed using guinea pigs and mice, and pathological findings associated with autumn crocus poisoning were compared with those of colchicine. Each group of guinea pigs given the bulb of autumn crocus or colchicine exhibited severe diarrhea. Histopathological findings in intoxicated guinea pigs were entirely consistent with those in the autumn crocus-poisoned cattle. In contrast, each group of mice administered with the bulb or... |
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Palavras-chave: Apoptosis; Autumn crocus (Colchicum autumnale L.); Colchicine; Guinea pig; Mouse. |
| Ano: 2000 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4170 |
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| TAWFEEQ, Mohammad Monir; MIURA, Saori; NAKANISHI, Yuuki; SUGIMOTO, Kazuya; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 古林, 与志安; 猪熊, 壽. |
| A 12-month-old Holstein heifer with anorexia, lameness, and enlargement of peripheral lymph nodes was suspected of having bovine leukosis. Although lymphocytosis was not observed, cytology of fine needle aspirate from a superficial cervical node, and increased serum lactate dehydrogenase and thymidine kinase activities, strongly suggested lymphosarcoma. Increased numbers of mononuclear cells as well as mitotic cells were observed in synovial fluid collected from swollen joints. Pathological examination confirmed B-cell calf form bovine leukosis and joint swelling related to neoplastic cell infiltration. Both interleukin-2 receptor and thymidine kinase 1 genes were highly expressed in cells from superficial cervical lymph node aspirate. |
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Palavras-chave: Calf form bovine leukosis; Gene expression; Joint infiltration. |
| Ano: 2012 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4097 |
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| 猪熊, 壽; 滄木, 孝弘; 山川, 和宏; 竹内, 俊彦; 松本, 高太郎; 石井, 三都夫; 古林, 与志安; 古岡, 秀文; INOKUMA, Hisashi; AOKI, Takahiro; YAMAKAWA, Kazuhiro; TAKEUCHI, Toshihiko; MATSUMOTO, Kotaro; ISHII, Mitsuo; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi. |
| 病理学的に血様液貯留を特徴とする特発性心嚢水腫と診断された乳牛8症例（血様心嚢水貯留群）の臨床病理学的検査所見を回顧的に取りまとめ，心膜炎7症例（心膜炎群）の所見と比較した．血様心嚢水貯留群では冷性浮腫を呈する症例が心膜炎群に比べて多かったが，その他の臨床症状には両群で差がなかった．心エコー検査では血様心嚢水貯留群では，心膜炎でみられる心嚢内の顕著なフィブリン析出はなかった．血液及び生化学検査では，血様心嚢水貯留群では炎症像が弱く，心膜炎群と比較して白血球数，分葉核好中球割合，A/G比，アルブミン濃度，γグロブリン割合に有意差がみられた．両群でALP及びGGTの高値がみられたが，特に血様心嚢水貯留群のGGT増加は顕著であった．血様心嚢水貯留症例の診断は臨床症状だけでは困難であるが，心エコー検査所見，弱い炎症像，ALP及びGGTの高値などが心膜炎との鑑別診断に有用と考えられた． Clinicopathological findings of eight cases of idiopathic hydropericardium characterized by bloodhlike fluid (HBFhgroup) that were confirmed by necropsy were retrospectively summarized and compared with those of seven cows with pericarditis. Although the numbers of cows that showed edema in the HBFhgroup were larger than those in the pericarditishgroup, the frequency of... |
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Palavras-chave: 特発性心餒水腫; 心膜炎; 血様心嚢水; 牛; Idiopathic hydropericardium; Pericarditis; Blood-like pericardium; Cow. |
| Ano: 2012 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3557 |
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| NISHIMURA, Maki; TOYOTA, Yumi; ISHIDA, Yoshikazu; NAKAYA, Hideki; KAMEYAMA, Kyohko; NISHIKAWA, Yoshifumi; MIYAHARA, Kazuro; INOKUMA, Hisashi; FURUOKA, Hidefumi; 西川, 義文; 猪熊, 壽; 古岡, 秀文. |
| A 9-month-old steer was autopsied due to recurrent ruminal tympany. A macroscopic examination found an enlarged caudal mediastinal lymph node, and a section of the lymph node revealed necrosis with marked calcification, similar to tuberculous lymphadenitis. Histopathologically, the lesion consisted of multiple coagulative necrotic foci and fibrosis with macrophage, lymphocyte, eosinophil and multinucleated giant cell infiltration. Non-uniform width hyphae were detected in the necrotic area and within the cytoplasm of the multinucleated giant cells, and they were found to be anti-Rhizopus arrhizus antibody positive in an immunohistochemical examination. Therefore, the steer was diagnosed with necrotic caudal mediastinal lymphadenitis due to zygomycetes... |
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Palavras-chave: Cattle; Necrotic lymphadenitis; Ruminal tympany; Zygomycosis. |
| Ano: 2014 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3943 |
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| 猪熊, 壽; 吉林台; 下田, 崇; 富樫, 義彦; 古林, 与志安; 古岡, 秀文; 佐藤, 基佳; 石井, 三都夫; INOKUMA, Hisashi; Jilintai; SHIMODA, Takashi; TOGASHl, Yoshihiko; KOBAYASHl, Yoshiyasu; FURUOKA, Hidefumi; SATHO, Motoyoshi; ISHI, Mitsuo. |
| 1 歳10 カ月のホルスタイン種育成雌牛が，初診時食欲不振，削痩，チアノーゼ，肺音粗励，発咳等の症状を呈した． さらに第14病日には頻脈，頸静脈拍動等の循環器症状が認められた．血液および血液生化学検査により慢性炎症像が， また心エコー検査により右心房内に三尖弁と付着しない高エコー占拠性病変が観察された．本症例は病理解剖により後 大静脈血栓症と診断されたが，血栓が心臓内において描出されたまれな症例と思われた． A 22-month-old，Holstein heifer was presented with anorexia，emaciation，cyanosis，rough vesicular breathing， and coughing on the first day. On day 14， cardiovascular symptoms such as tachycardia and jugular vein pulsation were found. A blood and blood biochemical examination revealed chronic inflammation. High echogenic obstruction without any attachment to the tricuspid valve was observed in the right atrium by echocardiograph. Pathological findings confirmed a diagnosis of caudal vena cava thrombosis. It was believed to be a rare case with thrombus in the... |
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Palavras-chave: 後大静脈血栓症; 心エコー検査; Caudal vena cava thrombosis; Echocardiography. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2805 |
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| MAGATA, Fumie; ISHIDA, Yoshikazu; MIYAMOTO, Akio; FURUOKA, Hidefumi; INOKUMA, Hisashi; SHIMIZU, Takashi; 宮本, 明夫; 古岡, 秀文; 猪熊, 壽; 清水, 隆. |
| We investigated the concentration of the bacterial endotoxin lipopolysaccharide (LPS) in the blood, ovarian follicular fluid and uterine fluid of a clinical case of bovine metritis. A 2-year-old lactating Holstein cow exhibited continuous fever >39.5°C for more than 2 weeks after normal calving. The cow produced a fetid, watery, red-brown uterine discharge from the vagina and was diagnosed with metritis. The LPS concentrations in plasma and uterine fluid were 0.94 and 6.34 endotoxin units (EU)/ml, respectively. One of seven follicles showed an extremely high level of LPS (12.40 EU/ml) compared to the other follicles (0.62–0.97 EU/ml). These results might suggest the presence of high concentration of LPS in follicles in cows with postpartum metritis. |
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Palavras-chave: Dairy cow; Follicle; Lipopolysaccharide; Metritis. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4043 |
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| 猪熊, 壽; 滄木, 孝弘; 松本, 高太郎; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; INOKUMA, Hisashi; AOKI, Takahiro; MATSUMOTO, Kotaro; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi. |
| Ano: 2015 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4145 |
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| 吉本, 薫; 海老名, 千尋; 高橋, 英二; 古岡, 秀文; 松本, 高太郎; 松井, 基純; 三宅, 陽一; 猪熊, 壽; YOSHIMOTO, Kaoru; EBINA, Chihiro; TAKAHASHI, Eiji; FURUOKA, Hidefumi; MATSUMOTO, Kotaro; MATSUI, Motozumi; MIYAKE, Yo-ichi; INOKUMA, Hisashi. |
| 排尿異常を認める21カ月齢の褐毛和種フリーマーチン肥育牛が，臨床的に水腎症および腎不全と診断された. 病理学的検査において，泌尿生殖器の重度雄性化，腎膿瘍および尿路結石が明らかとなった. 本症例は異常な尿道形態から尿路感染症と尿石症を継発し，最終的に腎後性腎不全に陥ったまれなフリーマーチン症例である. A Japanese Brown freemartin (21 months old) was clinically diagnosed with hydroneprosis and renal failure. A pathological examination revealed severe masculinization of the urogenital organs， pyonephritis and urolithiasis. These findings suggested that it was a rare case of a freemartin with a post-renal failure and morphological anomaly of the urinary tract，complicated by a bacterial infection and urolithiasis. 一一一Keywords :fr eemartin，po st-renal failure，se vere masculinization |
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Palavras-chave: フリーマーチン; 腎後性腎不全; 重度雄性化; Freemartin; Post-renal failure; Severe masculinization. |
| Ano: 2010 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2944 |
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| 松山, 雄喜; 神尾, 恭平; 村上, 智亮; 下田, 崇; 古林, 与志安; 古岡, 秀文; 松本, 高太郎; 猪熊, 壽; MATSUYAMA, Yuuki; KAMIO, Kyouhei; MURAKAMI, Tomoaki; SHIMODA, Takashi; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; MATSUMOTO, Kohtaro; INOKUMA, Hisashi. |
| 5 歳6 カ月齢ホルスタイン種乳牛が，後躯麻痺による起立不能を呈した．浅頸リンパ節の腫大と直腸検査による腫瘤 の触知から牛白血病を疑ったが，血液検査とリンパ節の針吸引生検では確定診断できなかった．剖検では，60 × 40 × 20cm 大の多結節性腫瘤が背側の腹腔壁に接して存在していた．腫瘍組織は腸腰筋に浸潤し，一部は第5 および第6 腰 椎椎間孔より脊柱管内に連続的に波及し，脊髄および脊髄神経根を圧迫していた．腫瘍はCD3 陽性のT細胞性リンパ 腫で，牛白血病ウイルス抗体陰性であったため，散発型牛白血病と診断された． A Holstein cow (5 years and 3 months old) presented with hind limb paresis and was unable to stand. Bovine leukosis was suspected given the enlargement of cervical lymph nodes and existence of an abdominal mass detected by rectal palpation; however，it could not be confirmed by blood examination and fine needle aspiration of cervical lymph nodes. Pathological examination revealed a mu1tinodular mass (60 x 40 x 20 cm) on the dorsal abdomen that was invasive into the iliopsoas muscle. A portion of the... |
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Palavras-chave: 牛白血病; 脊髄浸潤; 後躯麻痺; Bovine leukosis; Spinal cord invasion; Hind limb paresis. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2809 |
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| TAWFEEQ, Mohammad Monir; MIURA, Saori; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; 猪熊, 壽. |
| This study evaluated the clinical usefulness of serum thymidine kinase (TK) activity for diagnosing bovine leukosis cases for which clinical diagnosis was difficult (‘BL with difficult diagnosis’). Median TK activity values in 24 ‘BL with difficult diagnosis’ and 36 cattle for which BL was clinically confirmed by cytology findings of enlarged superficial lymph nodes (‘clinically confirmed BL’) were 36.8 and 39.4 U/l, respectively (no significant difference). The percentage with positive TK activity (>5.4 U/l) was also similar in both groups (83.3% for ‘BL with difficult diagnosis’ and 97.2% for ‘clinically confirmed BL’). TK activity was significantly higher in cows with ‘BL with difficult diagnosis’ compared to those with other tumors (N=13) and those... |
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Palavras-chave: Atypical bovine leukosis; Diagnosis; Thymidine kinase. |
| Ano: 2013 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3869 |
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| 田川, 道人; 谷, 夏深; 梶原, 綾乃; 古林, 与志安; 古岡, 秀文; 松井, 高峯; 石井, 三都夫; 猪熊, 壽; TAGAWA, Michihito; TANI, Natsumi; KAJIWARA, Ayano; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; MATSUMOTO, Kohtaro; ISHII, Mitsuo; INOKUMA, Hisashi. |
| 10 カ月齢のホルスタイン種雌育成牛が急性に斜頸，旋回，後弓反張，意識混濁の症状を呈した．大脳皮質壊死症を疑 い，ビタミンB1 製剤，コルチコステロイドおよび抗生物質による治療を実施したが反応せず，予後不良と判定された． 病理解剖により小脳に直径35. cm 大の腫瘤が確認され，左右側脳室および中脳水道の拡張がみられた．本症例は小脳腫 瘍による周辺部の圧迫および腫瘍の二次的圧迫による脳脊髄液流出障害により発生した内水頭症により，小脳徴候だけ でなく大脳および脳幹症状も出現したものと考えられた．病理組織学的検索の結果，本症例は上衣芽腫と診断された． A 10-month-old female Holstein heifer showed a sudden onset of clinical symptoms of head tilt，circling， increased extensor tone of all legs. and decreased level of consciousness. Cerebrocortical necrosis was suspected， and an administration of vitamin B1， corticosteroids，and anti-biotic was performed without a successful response. At necropsy，a neoplastic mass with a diameter of 3.5 cm in the cerebellum，dilated lateral ventricles on both sides and enlargement of the aqueducts cerebra... |
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Palavras-chave: 牛; 上衣芽腫; 神経症状; Cattle; Ependymoblastoma; Neurological signs. |
| Ano: 2009 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2807 |
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| 立石, 識子; 古林, 与志安; 黒沢, 重人; 大林, 哲; 古岡, 秀文; 松井, 高峯; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi. |
| 直腸検査により, 左腎相当部に巨大腫瘤が触知された4歳齢, 雌のホルスタイン牛を病理学的に検索した. 肉眼的に左腎は硬く, 褪色し, 分葉構造を保ちつつ顕著に腫大していた. 左腎割面では腎実質の大部分は白色硬組織により置換されていた. また, 左腎門リンパ節から左内腸骨リンパ節にかけて直径1-10cmの白色硬組織からなる腫瘤が密在していた. 組織所見では左腎に著しい結合組織増生を伴う上皮性腫瘍細胞の不整管状増殖がび漫性に認められ, 実質を置換していた. 同様の腫瘍組織は他の白色硬組織でも観察された. これらの腫瘍細胞は抗ウロモジュリン抗体に陽性を示した. 超微形態学的に腫瘍細胞には微絨毛とデスモゾームが認められた. 以上の所見から本症例を顕著な結合組織の増生を伴う腎細胞癌と診断した. |
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Palavras-chave: 牛; 腎細胞癌; ウロモジュリン. |
| Ano: 2005 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4171 |
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| Registros recuperados: 27 | |
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