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Central chemoreceptors and neural mechanisms of cardiorespiratory control BJMBR
Takakura,A.C.; Damasceno,R.S.; Falquetto,B.; Totola,L.T.; Sobrinho,C.R.; Ragioto,D.T.; Zolezi,F.P..
The arterial partial pressure (P CO2) of carbon dioxide is virtually constant because of the close match between the metabolic production of this gas and its excretion via breathing. Blood gas homeostasis does not rely solely on changes in lung ventilation, but also to a considerable extent on circulatory adjustments that regulate the transport of CO2 from its sites of production to the lungs. The neural mechanisms that coordinate circulatory and ventilatory changes to achieve blood gas homeostasis are the subject of this review. Emphasis will be placed on the control of sympathetic outflow by central chemoreceptors. High levels of CO2 exert an excitatory effect on sympathetic outflow that is mediated by specialized chemoreceptors such as the neurons...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemoreflex; Cardiorespiratory responses; Ventrolateral medulla; Sympathetic nerve activity; Phrenic nerve activity.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900009
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